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| 001 | 157096 | ||
| 005 | 20240229123129.0 | ||
| 024 | 7 | _ | |a 10.1016/j.isci.2020.101104 |2 doi |
| 024 | 7 | _ | |a pmid:32428859 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC7232089 |2 pmc |
| 024 | 7 | _ | |a altmetric:80674871 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2020-01387 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 050 |
| 100 | 1 | _ | |a Demaria, Maria C |b 0 |
| 245 | _ | _ | |a Tetraspanin CD53 Promotes Lymphocyte Recirculation by Stabilizing L-Selectin Surface Expression. |
| 260 | _ | _ | |a St. Louis |c 2020 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1594726652_26624 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Tetraspanins regulate key processes in immune cells; however, the function of the leukocyte-restricted tetraspanin CD53 is unknown. Here we show that CD53 is essential for lymphocyte recirculation. Lymph nodes of Cd53-/- mice were smaller than those of wild-type mice due to a marked reduction in B cells and a 50% decrease in T cells. This reduced cellularity reflected an inability of Cd53-/- B and T cells to efficiently home to lymph nodes, due to the near absence of L-selectin from Cd53-/- B cells and reduced stability of L-selectin on Cd53-/- T cells. Further analyses, including on human lymphocytes, showed that CD53 stabilizes L-selectin surface expression and may restrain L-selectin shedding via both ADAM17-dependent and ADAM17-independent mechanisms. The disruption in lymphocyte recirculation in Cd53-/- mice led to impaired immune responses dependent on antigen delivery to lymph nodes. Together these findings demonstrate an essential role for CD53 in lymphocyte trafficking and immunity. |
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| 700 | 1 | _ | |a Yeung, Louisa |b 1 |
| 700 | 1 | _ | |a Peeters, Rens |b 2 |
| 700 | 1 | _ | |a Wee, Janet L |b 3 |
| 700 | 1 | _ | |a Mihaljcic, Masa |b 4 |
| 700 | 1 | _ | |a Jones, Eleanor L |b 5 |
| 700 | 1 | _ | |a Nasa, Zeyad |b 6 |
| 700 | 1 | _ | |a Alderuccio, Frank |b 7 |
| 700 | 1 | _ | |a Hall, Pamela |b 8 |
| 700 | 1 | _ | |a Smith, Brodie C |b 9 |
| 700 | 1 | _ | |a Binger, Katrina J |b 10 |
| 700 | 1 | _ | |a Hammerling, Gunther |0 P:(DE-HGF)0 |b 11 |
| 700 | 1 | _ | |a Kwok, Hang Fai |b 12 |
| 700 | 1 | _ | |a Newman, Andrew |b 13 |
| 700 | 1 | _ | |a Ager, Ann |b 14 |
| 700 | 1 | _ | |a van Spriel, Annemiek |b 15 |
| 700 | 1 | _ | |a Hickey, Michael J |b 16 |
| 700 | 1 | _ | |a Wright, Mark D |b 17 |
| 773 | _ | _ | |a 10.1016/j.isci.2020.101104 |g Vol. 23, no. 5, p. 101104 - |0 PERI:(DE-600)2927064-9 |n 5 |p 101104 |t iScience |v 23 |y 2020 |x 2589-0042 |
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| 910 | 1 | _ | |a Deutsches Krebsforschungszentrum |0 I:(DE-588b)2036810-0 |k DKFZ |b 11 |6 P:(DE-HGF)0 |
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| 914 | 1 | _ | |y 2020 |
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