000157141 001__ 157141
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000157141 0247_ $$2doi$$a10.1016/j.ccell.2020.06.004
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000157141 1001_ $$aGojo, Johannes$$b0
000157141 245__ $$aSingle-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma.
000157141 260__ $$aNew York, NY$$bElsevier$$c2020
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000157141 520__ $$aEpendymoma is a heterogeneous entity of central nervous system tumors with well-established molecular groups. Here, we apply single-cell RNA sequencing to analyze ependymomas across molecular groups and anatomic locations to investigate their intratumoral heterogeneity and developmental origins. Ependymomas are composed of a cellular hierarchy initiating from undifferentiated populations, which undergo impaired differentiation toward three lineages of neuronal-glial fate specification. While prognostically favorable groups of ependymoma predominantly harbor differentiated cells, aggressive groups are enriched for undifferentiated cell populations. The delineated transcriptomic signatures correlate with patient survival and define molecular dependencies for targeted treatment approaches. Taken together, our analyses reveal a developmental hierarchy underlying ependymomas relevant to biological and clinical behavior.
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000157141 7001_ $$aEnglinger, Bernhard$$b1
000157141 7001_ $$aJiang, Li$$b2
000157141 7001_ $$0P:(DE-He78)a8c698e0904394407c5261932915daa5$$aHübner, Jens M$$b3
000157141 7001_ $$aShaw, McKenzie L$$b4
000157141 7001_ $$aHack, Olivia A$$b5
000157141 7001_ $$aMadlener, Sibylle$$b6
000157141 7001_ $$aKirchhofer, Dominik$$b7
000157141 7001_ $$aLiu, Ilon$$b8
000157141 7001_ $$aPyrdol, Jason$$b9
000157141 7001_ $$aHovestadt, Volker$$b10
000157141 7001_ $$aMazzola, Emanuele$$b11
000157141 7001_ $$aMathewson, Nathan D$$b12
000157141 7001_ $$aTrissal, Maria$$b13
000157141 7001_ $$aLötsch, Daniela$$b14
000157141 7001_ $$aDorfer, Christian$$b15
000157141 7001_ $$aHaberler, Christine$$b16
000157141 7001_ $$aHalfmann, Angela$$b17
000157141 7001_ $$aMayr, Lisa$$b18
000157141 7001_ $$aPeyrl, Andreas$$b19
000157141 7001_ $$aGeyeregger, Rene$$b20
000157141 7001_ $$0P:(DE-He78)9ce969bf1ac7913b3f2b1cf4dd7f823e$$aSchwalm, Benjamin$$b21
000157141 7001_ $$aMauermann, Monica$$b22
000157141 7001_ $$0P:(DE-He78)a7c1bbac024fa232d9c6b78443328d9d$$aPajtler, Kristian W$$b23
000157141 7001_ $$0P:(DE-He78)0be2f86573954f87e97f8a4dbb05cb0f$$aMilde, Till$$b24
000157141 7001_ $$aShore, Marni E$$b25
000157141 7001_ $$aGeduldig, Jack E$$b26
000157141 7001_ $$aPelton, Kristine$$b27
000157141 7001_ $$aCzech, Thomas$$b28
000157141 7001_ $$aAshenberg, Orr$$b29
000157141 7001_ $$aWucherpfennig, Kai W$$b30
000157141 7001_ $$aRozenblatt-Rosen, Orit$$b31
000157141 7001_ $$aAlexandrescu, Sanda$$b32
000157141 7001_ $$aLigon, Keith L$$b33
000157141 7001_ $$0P:(DE-He78)f746aa965c4e1af518b016de3aaff5d9$$aPfister, Stefan M$$b34
000157141 7001_ $$aRegev, Aviv$$b35
000157141 7001_ $$aSlavc, Irene$$b36
000157141 7001_ $$aBerger, Walter$$b37
000157141 7001_ $$aSuvà, Mario L$$b38
000157141 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b39$$eLast author
000157141 7001_ $$aFilbin, Mariella G$$b40
000157141 773__ $$0PERI:(DE-600)2074034-7$$a10.1016/j.ccell.2020.06.004$$gVol. 38, no. 1, p. 44 - 59.e9$$n1$$p44 - 59.e9$$tCancer cell$$v38$$x1535-6108$$y2020
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