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@ARTICLE{Gojo:157141,
      author       = {J. Gojo and B. Englinger and L. Jiang and J. M. Hübner$^*$
                      and M. L. Shaw and O. A. Hack and S. Madlener and D.
                      Kirchhofer and I. Liu and J. Pyrdol and V. Hovestadt and E.
                      Mazzola and N. D. Mathewson and M. Trissal and D. Lötsch
                      and C. Dorfer and C. Haberler and A. Halfmann and L. Mayr
                      and A. Peyrl and R. Geyeregger and B. Schwalm$^*$ and M.
                      Mauermann and K. W. Pajtler$^*$ and T. Milde$^*$ and M. E.
                      Shore and J. E. Geduldig and K. Pelton and T. Czech and O.
                      Ashenberg and K. W. Wucherpfennig and O. Rozenblatt-Rosen
                      and S. Alexandrescu and K. L. Ligon and S. M. Pfister$^*$
                      and A. Regev and I. Slavc and W. Berger and M. L. Suvà and
                      M. Kool$^*$ and M. G. Filbin},
      title        = {{S}ingle-{C}ell {RNA}-{S}eq {R}eveals {C}ellular
                      {H}ierarchies and {I}mpaired {D}evelopmental {T}rajectories
                      in {P}ediatric {E}pendymoma.},
      journal      = {Cancer cell},
      volume       = {38},
      number       = {1},
      issn         = {1535-6108},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2020-01427},
      pages        = {44 - 59.e9},
      year         = {2020},
      note         = {#LA:B062#},
      abstract     = {Ependymoma is a heterogeneous entity of central nervous
                      system tumors with well-established molecular groups. Here,
                      we apply single-cell RNA sequencing to analyze ependymomas
                      across molecular groups and anatomic locations to
                      investigate their intratumoral heterogeneity and
                      developmental origins. Ependymomas are composed of a
                      cellular hierarchy initiating from undifferentiated
                      populations, which undergo impaired differentiation toward
                      three lineages of neuronal-glial fate specification. While
                      prognostically favorable groups of ependymoma predominantly
                      harbor differentiated cells, aggressive groups are enriched
                      for undifferentiated cell populations. The delineated
                      transcriptomic signatures correlate with patient survival
                      and define molecular dependencies for targeted treatment
                      approaches. Taken together, our analyses reveal a
                      developmental hierarchy underlying ependymomas relevant to
                      biological and clinical behavior.},
      cin          = {B062 / B310},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)B310-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32663469},
      doi          = {10.1016/j.ccell.2020.06.004},
      url          = {https://inrepo02.dkfz.de/record/157141},
}