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000157159 1001_ $$0P:(DE-He78)07eef6d38a91f4642c810745c5bf5000$$aAhadova, Aysel$$b0$$eFirst author$$udkfz
000157159 245__ $$aThe 'unnatural' history of colorectal cancer in Lynch syndrome: lessons from colonoscopy surveillance.
000157159 260__ $$aBognor Regis$$bWiley-Liss$$c2021
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000157159 520__ $$aIndividuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are a matter of debate. In this review, we collect existing evidence from clinical, epidemiological and molecular studies and interpret them with regard to the origins and progression of LS-associated CRC. Alongside with hypotheses addressing colonoscopy quality and pace of progression from adenoma to cancer, we discuss the role of alternative precursors and of immune system in LS-associated CRC. We also identify gaps in current knowledge and make suggestions for future studies aiming at improved CRC prevention for LS individuals. This article is protected by copyright. All rights reserved.
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000157159 7001_ $$aSeppälä, Toni T$$b1
000157159 7001_ $$00000-0002-7247-282X$$aEngel, Christoph$$b2
000157159 7001_ $$aGallon, Richard$$b3
000157159 7001_ $$aBurn, John$$b4
000157159 7001_ $$aHolinski-Feder, Elke$$b5
000157159 7001_ $$00000-0001-8491-3234$$aSteinke-Lange, Verena$$b6
000157159 7001_ $$aMöslein, Gabriela$$b7
000157159 7001_ $$aNielsen, Maartje$$b8
000157159 7001_ $$aTen Broeke, Sanne$$b9
000157159 7001_ $$aLaghi, Luigi$$b10
000157159 7001_ $$00000-0001-7856-0057$$aDominguez-Valentin, Mev$$b11
000157159 7001_ $$aCapella, Gabriel$$b12
000157159 7001_ $$aMacrae, Finlay$$b13
000157159 7001_ $$aScott, Rodney$$b14
000157159 7001_ $$aHüneburg, Robert$$b15
000157159 7001_ $$aNattermann, Jacob$$b16
000157159 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b17$$udkfz
000157159 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b18$$udkfz
000157159 7001_ $$aBläker, Hendrik$$b19
000157159 7001_ $$0P:(DE-He78)11747cd1dc061b9333c0e3a3ff31bf2f$$avon Knebel Doeberitz, Magnus$$b20$$udkfz
000157159 7001_ $$aSampson, Julian R$$b21
000157159 7001_ $$aVasen, Hans$$b22
000157159 7001_ $$aMecklin, Jukka-Pekka$$b23
000157159 7001_ $$aMøller, Pål$$b24
000157159 7001_ $$0P:(DE-He78)028ee60cca729028708496826f077b58$$aKloor, Matthias$$b25$$eLast author$$udkfz
000157159 773__ $$0PERI:(DE-600)1474822-8$$a10.1002/ijc.33224$$gp. ijc.33224$$n4$$p800-811$$tInternational journal of cancer$$v148$$x1097-0215$$y2021
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