Journal Article (Review Article)

DKFZ-2020-01439

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The 'unnatural' history of colorectal cancer in Lynch syndrome: lessons from colonoscopy surveillance.

Ahadova, A. (First author)DKFZ* ; Seppälä, T. T. ; Engel, C. ; Gallon, R. ; Burn, J. ; Holinski-Feder, E. ; Steinke-Lange, V. ; Möslein, G. ; Nielsen, M. ; Ten Broeke, S. ; Laghi, L. ; Dominguez-Valentin, M. ; Capella, G. ; Macrae, F. ; Scott, R. ; Hüneburg, R. ; Nattermann, J. ; Hoffmeister, M.DKFZ* ; Brenner, H.DKFZ* ; Bläker, H. ; von Knebel Doeberitz, M.DKFZ* ; Sampson, J. R. ; Vasen, H. ; Mecklin, J.-P. ; Møller, P. ; Kloor, M. (Last author)DKFZ*

2021
Wiley-Liss Bognor Regis

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/ijc.33224

Abstract: Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are a matter of debate. In this review, we collect existing evidence from clinical, epidemiological and molecular studies and interpret them with regard to the origins and progression of LS-associated CRC. Alongside with hypotheses addressing colonoscopy quality and pace of progression from adenoma to cancer, we discuss the role of alternative precursors and of immune system in LS-associated CRC. We also identify gaps in current knowledge and make suggestions for future studies aiming at improved CRC prevention for LS individuals. This article is protected by copyright. All rights reserved.

Note: #EA:F210#LA:F210#2021 Feb 15;148(4):800-811

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Contributing Institute(s):

1. Angewandte Tumorbiologie (F210)
2. C070 Klinische Epidemiologie und Alternf. (C070)
3. Präventive Onkologie (C120)
4. DKTK HD zentral (HD01)

Research Program(s):

1. 316 - Infektionen, Entzündung und Krebs (POF4-316) (POF4-316)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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