TY  - JOUR
AU  - Ahadova, Aysel
AU  - Seppälä, Toni T
AU  - Engel, Christoph
AU  - Gallon, Richard
AU  - Burn, John
AU  - Holinski-Feder, Elke
AU  - Steinke-Lange, Verena
AU  - Möslein, Gabriela
AU  - Nielsen, Maartje
AU  - Ten Broeke, Sanne
AU  - Laghi, Luigi
AU  - Dominguez-Valentin, Mev
AU  - Capella, Gabriel
AU  - Macrae, Finlay
AU  - Scott, Rodney
AU  - Hüneburg, Robert
AU  - Nattermann, Jacob
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
AU  - Bläker, Hendrik
AU  - von Knebel Doeberitz, Magnus
AU  - Sampson, Julian R
AU  - Vasen, Hans
AU  - Mecklin, Jukka-Pekka
AU  - Møller, Pål
AU  - Kloor, Matthias
TI  - The 'unnatural' history of colorectal cancer in Lynch syndrome: lessons from colonoscopy surveillance.
JO  - International journal of cancer
VL  - 148
IS  - 4
SN  - 1097-0215
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2020-01439
SP  - 800-811
PY  - 2021
N1  - #EA:F210#LA:F210#2021 Feb 15;148(4):800-811
AB  - Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are a matter of debate. In this review, we collect existing evidence from clinical, epidemiological and molecular studies and interpret them with regard to the origins and progression of LS-associated CRC. Alongside with hypotheses addressing colonoscopy quality and pace of progression from adenoma to cancer, we discuss the role of alternative precursors and of immune system in LS-associated CRC. We also identify gaps in current knowledge and make suggestions for future studies aiming at improved CRC prevention for LS individuals. This article is protected by copyright. All rights reserved.
LB  - PUB:(DE-HGF)16
C6  - pmid:32683684
DO  - DOI:10.1002/ijc.33224
UR  - https://inrepo02.dkfz.de/record/157159
ER  -