% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Ahadova:157159,
      author       = {A. Ahadova$^*$ and T. T. Seppälä and C. Engel and R.
                      Gallon and J. Burn and E. Holinski-Feder and V.
                      Steinke-Lange and G. Möslein and M. Nielsen and S. Ten
                      Broeke and L. Laghi and M. Dominguez-Valentin and G. Capella
                      and F. Macrae and R. Scott and R. Hüneburg and J.
                      Nattermann and M. Hoffmeister$^*$ and H. Brenner$^*$ and H.
                      Bläker and M. von Knebel Doeberitz$^*$ and J. R. Sampson
                      and H. Vasen and J.-P. Mecklin and P. Møller and M.
                      Kloor$^*$},
      title        = {{T}he 'unnatural' history of colorectal cancer in {L}ynch
                      syndrome: lessons from colonoscopy surveillance.},
      journal      = {International journal of cancer},
      volume       = {148},
      number       = {4},
      issn         = {1097-0215},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2020-01439},
      pages        = {800-811},
      year         = {2021},
      note         = {#EA:F210#LA:F210#2021 Feb 15;148(4):800-811},
      abstract     = {Individuals with Lynch syndrome (LS), one of the most
                      common inherited cancer syndromes, are at increased risk of
                      developing malignancies, in particular colorectal cancer
                      (CRC). Regular colonoscopy with polypectomy is recommended
                      to reduce CRC risk in LS individuals. However, recent
                      independent studies demonstrated that a substantial
                      proportion of LS individuals develop CRC despite regular
                      colonoscopy. The reasons for this surprising observation
                      confirmed by large prospective studies are a matter of
                      debate. In this review, we collect existing evidence from
                      clinical, epidemiological and molecular studies and
                      interpret them with regard to the origins and progression of
                      LS-associated CRC. Alongside with hypotheses addressing
                      colonoscopy quality and pace of progression from adenoma to
                      cancer, we discuss the role of alternative precursors and of
                      immune system in LS-associated CRC. We also identify gaps in
                      current knowledge and make suggestions for future studies
                      aiming at improved CRC prevention for LS individuals. This
                      article is protected by copyright. All rights reserved.},
      subtyp        = {Review Article},
      cin          = {F210 / C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)F210-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {316 - Infektionen, Entzündung und Krebs (POF4-316)},
      pid          = {G:(DE-HGF)POF4-316},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32683684},
      doi          = {10.1002/ijc.33224},
      url          = {https://inrepo02.dkfz.de/record/157159},
}