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@ARTICLE{deGuia:157414,
      author       = {R. M. de Guia$^*$},
      title        = {{S}tress, glucocorticoid signaling pathway, and metabolic
                      disorders.},
      journal      = {Diabetes $\&$ metabolic syndrome},
      volume       = {14},
      number       = {5},
      issn         = {1871-4021},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2020-01609},
      pages        = {1273 - 1280},
      year         = {2020},
      note         = {DKFZ-ZMBH Alliance#LA:A170#},
      abstract     = {Glucocorticoids and the GR serve as an essential molecular
                      mediator of stress and different physiologic processes. This
                      review summarizes main findings from studies on the role of
                      the GC/GR signaling in the modulation of genes for nutrient
                      processing by the different organs involved in metabolic
                      diseases.Descriptive review of relevant papers known to the
                      author was conducted.Several high-throughput screenings in
                      the past 15 years have identified potential GR DNA-binding
                      regions in different cell types with genes that are
                      annotated to be important for the control of metabolism.
                      Transcriptional regulation of these GC-responsive genes
                      provides links between the hypothalamic-pituitary-adrenal
                      axis (HPA) and systemic energy homeostasis in both
                      physiological and pathophysiological states. Future studies
                      must reconsider the use of agonist, the utilization of
                      animal models of stress and metabolic disorders, and
                      validation in humans.This review recapitulates the
                      significant role of the GC/GR signaling in molecular
                      metabolic control and metabolic disorders. Potential future
                      research focus and optimizations have also been identified.},
      subtyp        = {Review Article},
      cin          = {A170},
      ddc          = {610},
      cid          = {I:(DE-He78)A170-20160331},
      pnm          = {311 - Signalling pathways, cell and tumor biology
                      (POF3-311)},
      pid          = {G:(DE-HGF)POF3-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32755820},
      doi          = {10.1016/j.dsx.2020.06.038},
      url          = {https://inrepo02.dkfz.de/record/157414},
}