Journal Article (Review Article)

DKFZ-2020-01609

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Stress, glucocorticoid signaling pathway, and metabolic disorders.

de Guia, R. M. (Last author)DKFZ*

2020
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.dsx.2020.06.038

Abstract: Glucocorticoids and the GR serve as an essential molecular mediator of stress and different physiologic processes. This review summarizes main findings from studies on the role of the GC/GR signaling in the modulation of genes for nutrient processing by the different organs involved in metabolic diseases.Descriptive review of relevant papers known to the author was conducted.Several high-throughput screenings in the past 15 years have identified potential GR DNA-binding regions in different cell types with genes that are annotated to be important for the control of metabolism. Transcriptional regulation of these GC-responsive genes provides links between the hypothalamic-pituitary-adrenal axis (HPA) and systemic energy homeostasis in both physiological and pathophysiological states. Future studies must reconsider the use of agonist, the utilization of animal models of stress and metabolic disorders, and validation in humans.This review recapitulates the significant role of the GC/GR signaling in molecular metabolic control and metabolic disorders. Potential future research focus and optimizations have also been identified.

Note: DKFZ-ZMBH Alliance#LA:A170#

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Contributing Institute(s):

1. Molekulare Stoffwechselkontrolle (A170)

Research Program(s):

1. 311 - Signalling pathways, cell and tumor biology (POF3-311) (POF3-311)

Appears in the scientific report 2020

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Database coverage:
; Clarivate Analytics Master Journal List ; Emerging Sources Citation Index ; NCBI Molecular Biology Database ; SCOPUS ; Web of Science Core Collection

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