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@ARTICLE{Lee:157423,
      author       = {A. W. Lee and S. Rosenzweig and A. Wiensch and S. J. Ramus
                      and U. Menon and A. Gentry-Maharaj and A. Ziogas and H.
                      Anton-Culver and A. S. Whittemore and W. Sieh and J. H.
                      Rothstein and V. McGuire and N. Wentzensen and E. V. Bandera
                      and B. Qin and K. L. Terry and D. W. Cramer and L. Titus and
                      J. M. Schildkraut and A. Berchuck and E. L. Goode and S. K.
                      Kjaer and A. Jensen and S. J. Jordan and R. B. Ness and F.
                      Modugno and K. Moysich and P. J. Thompson and M. T. Goodman
                      and M. E. Carney and J. Chang-Claude$^*$ and M. A. Rossing
                      and H. R. Harris and J. A. Doherty and H. A. Risch and L.
                      Khoja and A. Alimujiang and M. T. Phung and K. Brieger and
                      B. Mukherjee and P. D. P. Pharoah and A. H. Wu and M. C.
                      Pike and P. M. Webb and C. L. Pearce},
      collaboration = {A. O. C. S. Group},
      title        = {{E}xpanding our understanding of ovarian cancer risk: the
                      role of incomplete pregnancies.},
      journal      = {Journal of the National Cancer Institute},
      volume       = {113},
      number       = {3},
      issn         = {1460-2105},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2020-01618},
      pages        = {301-308},
      year         = {2021},
      note         = {2021 Mar 1;113(3):301-308},
      abstract     = {Parity is associated with decreased risk of invasive
                      ovarian cancer; however, the relationship between incomplete
                      pregnancies and invasive ovarian cancer risk is unclear.
                      This relationship was examined using 15 case-control studies
                      from the Ovarian Cancer Association Consortium (OCAC).
                      Histotype-specific associations, which have not been
                      examined previously with large sample sizes, were also
                      evaluated.A pooled analysis of 10,470 invasive epithelial
                      ovarian cancer cases and 16,942 controls was conducted. Odds
                      ratios and $95\%$ confidence intervals for the association
                      between incomplete pregnancies and invasive epithelial
                      ovarian cancer were estimated using logistic regression. All
                      models were conditioned on OCAC study, race/ethnicity, age,
                      and education level, and adjusted for number of complete
                      pregnancies, oral contraceptive use, and history of
                      breastfeeding. The same approach was used for
                      histotype-specific analyses.Ever having an incomplete
                      pregnancy was associated with a $16\%$ reduction in ovarian
                      cancer risk (OR = 0.84, $95\%$ CI = 0.79 to 0.89).
                      There was a trend of decreasing risk with increasing number
                      of incomplete pregnancies (two-sided Ptrend <.001). An
                      inverse association was observed for all major histotypes;
                      it was strongest for clear cell ovarian cancer.Incomplete
                      pregnancies are associated with a reduced risk of invasive
                      epithelial ovarian cancer. Pregnancy, including incomplete
                      pregnancy, was associated with a greater reduction in risk
                      of clear cell ovarian cancer, but the result was broadly
                      consistent across histotypes. Future work should focus on
                      understanding the mechanisms underlying this reduced risk.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32766851},
      doi          = {10.1093/jnci/djaa099},
      url          = {https://inrepo02.dkfz.de/record/157423},
}