Journal Article

DKFZ-2020-01618

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Expanding our understanding of ovarian cancer risk: the role of incomplete pregnancies.

Lee, A. W. ; Rosenzweig, S. ; Wiensch, A. ; Group, A. O. C. S. (Collaboration Author) ; Ramus, S. J. ; Menon, U. ; Gentry-Maharaj, A. ; Ziogas, A. ; Anton-Culver, H. ; Whittemore, A. S. ; Sieh, W. ; Rothstein, J. H. ; McGuire, V. ; Wentzensen, N. ; Bandera, E. V. ; Qin, B. ; Terry, K. L. ; Cramer, D. W. ; Titus, L. ; Schildkraut, J. M. ; Berchuck, A. ; Goode, E. L. ; Kjaer, S. K. ; Jensen, A. ; Jordan, S. J. ; Ness, R. B. ; Modugno, F. ; Moysich, K. ; Thompson, P. J. ; Goodman, M. T. ; Carney, M. E. ; Chang-Claude, J.DKFZ* ; Rossing, M. A. ; Harris, H. R. ; Doherty, J. A. ; Risch, H. A. ; Khoja, L. ; Alimujiang, A. ; Phung, M. T. ; Brieger, K. ; Mukherjee, B. ; Pharoah, P. D. P. ; Wu, A. H. ; Pike, M. C. ; Webb, P. M. ; Pearce, C. L.

2021
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/jnci/djaa099

Abstract: Parity is associated with decreased risk of invasive ovarian cancer; however, the relationship between incomplete pregnancies and invasive ovarian cancer risk is unclear. This relationship was examined using 15 case-control studies from the Ovarian Cancer Association Consortium (OCAC). Histotype-specific associations, which have not been examined previously with large sample sizes, were also evaluated.A pooled analysis of 10,470 invasive epithelial ovarian cancer cases and 16,942 controls was conducted. Odds ratios and 95% confidence intervals for the association between incomplete pregnancies and invasive epithelial ovarian cancer were estimated using logistic regression. All models were conditioned on OCAC study, race/ethnicity, age, and education level, and adjusted for number of complete pregnancies, oral contraceptive use, and history of breastfeeding. The same approach was used for histotype-specific analyses.Ever having an incomplete pregnancy was associated with a 16% reduction in ovarian cancer risk (OR = 0.84, 95% CI = 0.79 to 0.89). There was a trend of decreasing risk with increasing number of incomplete pregnancies (two-sided Ptrend <.001). An inverse association was observed for all major histotypes; it was strongest for clear cell ovarian cancer.Incomplete pregnancies are associated with a reduced risk of invasive epithelial ovarian cancer. Pregnancy, including incomplete pregnancy, was associated with a greater reduction in risk of clear cell ovarian cancer, but the result was broadly consistent across histotypes. Future work should focus on understanding the mechanisms underlying this reduced risk.

Note: 2021 Mar 1;113(3):301-308

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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