TY  - JOUR
AU  - Niedermaier, Tobias
AU  - Balavarca, Yesilda
AU  - Brenner, Hermann
TI  - Stage-Specific Sensitivity of Fecal Immunochemical Tests for Detecting Colorectal Cancer: Systematic Review and Meta-Analysis.
JO  - The American journal of gastroenterology
VL  - 115
IS  - 1
SN  - 0002-9270
CY  - Alphen aan den Rijn, The Netherlands
PB  - Wolters Kluwer Health, Inc.
M1  - DKFZ-2020-01688
SP  - 56 - 69
PY  - 2020
N1  - in PubMed: Meta-Analysis#EA:C070#LA:C070#
AB  - Fecal immunochemical tests (FITs) detect the majority of colorectal cancers (CRCs), but evidence for variation in sensitivity according to the CRC stage is sparse and has not yet been systematically synthesized. Thus, our objective was to systematically review and summarize evidence on the stage-specific sensitivity of FITs.We screened PubMed, Web of Science, Embase, and the Cochrane Library from inception to June 14, 2019, for English-language articles reporting on the stage-specific sensitivity of FIT for CRC detection using colonoscopy as a reference standard. Studies reporting stage-specific sensitivities and the specificity of FIT for CRC detection were included. Summary estimates of sensitivity according to the CRC stage and study setting (screening cohorts, symptomatic/diagnostic cohorts, and case-control studies) were derived from bivariate meta-analysis.Forty-four studies (92,447 participants including 3,034 CRC cases) were included. Pooled stage-specific sensitivities were overall very similar but suffered from high levels of imprecision because of small case numbers when calculated separately for screening cohorts, symptomatic/diagnostic cohorts, and case-control studies. Pooled sensitivities (95
KW  - Biomarkers, Tumor: analysis
KW  - Colonoscopy
KW  - Colorectal Neoplasms: diagnosis
KW  - Colorectal Neoplasms: metabolism
KW  - Early Detection of Cancer: methods
KW  - Feces: chemistry
KW  - Humans
KW  - Immunochemistry
KW  - Neoplasm Staging: methods
KW  - Biomarkers, Tumor (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:31850933
C2  - pmc:PMC6946106
DO  - DOI:10.14309/ajg.0000000000000465
UR  - https://inrepo02.dkfz.de/record/157533
ER  -