% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Niedermaier:157533,
      author       = {T. Niedermaier$^*$ and Y. Balavarca$^*$ and H. Brenner$^*$},
      title        = {{S}tage-{S}pecific {S}ensitivity of {F}ecal
                      {I}mmunochemical {T}ests for {D}etecting {C}olorectal
                      {C}ancer: {S}ystematic {R}eview and {M}eta-{A}nalysis.},
      journal      = {The American journal of gastroenterology},
      volume       = {115},
      number       = {1},
      issn         = {0002-9270},
      address      = {Alphen aan den Rijn, The Netherlands},
      publisher    = {Wolters Kluwer Health, Inc.},
      reportid     = {DKFZ-2020-01688},
      pages        = {56 - 69},
      year         = {2020},
      note         = {in PubMed: Meta-Analysis#EA:C070#LA:C070#},
      abstract     = {Fecal immunochemical tests (FITs) detect the majority of
                      colorectal cancers (CRCs), but evidence for variation in
                      sensitivity according to the CRC stage is sparse and has not
                      yet been systematically synthesized. Thus, our objective was
                      to systematically review and summarize evidence on the
                      stage-specific sensitivity of FITs.We screened PubMed, Web
                      of Science, Embase, and the Cochrane Library from inception
                      to June 14, 2019, for English-language articles reporting on
                      the stage-specific sensitivity of FIT for CRC detection
                      using colonoscopy as a reference standard. Studies reporting
                      stage-specific sensitivities and the specificity of FIT for
                      CRC detection were included. Summary estimates of
                      sensitivity according to the CRC stage and study setting
                      (screening cohorts, symptomatic/diagnostic cohorts, and
                      case-control studies) were derived from bivariate
                      meta-analysis.Forty-four studies (92,447 participants
                      including 3,034 CRC cases) were included. Pooled
                      stage-specific sensitivities were overall very similar but
                      suffered from high levels of imprecision because of small
                      case numbers when calculated separately for screening
                      cohorts, symptomatic/diagnostic cohorts, and case-control
                      studies. Pooled sensitivities $(95\%$ confidence intervals)
                      for all studies combined were $73\%$ $(65\%-79\%)$ for
                      stage-I-CRCs and $80\%$ $(74\%-84\%),$ $82\%$ $(77\%-87\%),$
                      and $79\%$ $(70\%-86\%)$ for the detection of CRC stages II,
                      III, and IV, respectively. Even substantially larger
                      variation was seen in sensitivity by T-stage, with summary
                      estimates ranging from $40\%$ $(21\%-64\%)$ for T1 to $83\%$
                      $(68\%-91\%)$ for T3-CRC.Although FITs detect 4 of 5 CRCs at
                      stages II-IV, the substantially lower sensitivity for
                      stage-I-CRC and, in particular, T1 CRC indicates both need
                      and potential for further improvement in performance for the
                      early detection of CRC.},
      subtyp        = {Review Article},
      keywords     = {Biomarkers, Tumor: analysis / Colonoscopy / Colorectal
                      Neoplasms: diagnosis / Colorectal Neoplasms: metabolism /
                      Early Detection of Cancer: methods / Feces: chemistry /
                      Humans / Immunochemistry / Neoplasm Staging: methods /
                      Biomarkers, Tumor (NLM Chemicals)},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31850933},
      pmc          = {pmc:PMC6946106},
      doi          = {10.14309/ajg.0000000000000465},
      url          = {https://inrepo02.dkfz.de/record/157533},
}