%0 Journal Article
%A Hidaka, Akihisa
%A Harrison, Tabitha A
%A Cao, Yin
%A Sakoda, Lori C
%A Barfield, Richard
%A Giannakis, Marios
%A Song, Mingyang
%A Phipps, Amanda I
%A Figueiredo, Jane C
%A Zaidi, Syed H
%A Toland, Amanda E
%A Amitay, Efrat
%A Berndt, Sonja I
%A Borozan, Ivan
%A Chan, Andrew T
%A Gallinger, Steven
%A Gunter, Marc J
%A Guinter, Mark A
%A Harlid, Sophia
%A Hampel, Heather
%A Jenkins, Mark A
%A Lin, Yi
%A Moreno, Victor
%A Newcomb, Polly A
%A Nishihara, Reiko
%A Ogino, Shuji
%A Obón-Santacana, Mireia
%A Parfrey, Patrick S
%A Potter, John D
%A Slattery, Martha L
%A Steinfelder, Robert S
%A Um, Caroline Y
%A Wang, Xiaoliang
%A Woods, Michael O
%A Van Guelpen, Bethany
%A Thibodeau, Stephen N
%A Hoffmeister, Michael
%A Sun, Wei
%A Hsu, Li
%A Buchanan, Daniel D
%A Campbell, Peter T
%A Peters, Ulrike
%T Intake of dietary fruit, vegetables, and fiber and risk of colorectal cancer according to molecular subtypes: A pooled analysis of 9 studies.
%J Cancer research
%V 80
%N 20
%@ 1538-7445
%C Philadelphia, Pa.
%I AACR
%M DKFZ-2020-01714
%P 4578-4590
%D 2020
%Z 2020 Oct 15;80(20):4578-4590
%X Protective associations of fruits, vegetables, and fiber intake with colorectal cancer (CRC) risk have been shown in many, but not all epidemiological studies. One possible reason for study heterogeneity is that dietary factors may have distinct effects by CRC molecular subtypes. Here we investigate the association of fruit, vegetables, and fiber intake with four well-established CRC molecular subtypes separately and in combination. Nine observational studies including 9,592 cases with molecular subtypes for microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and somatic mutations in BRAF and KRAS genes, and 7,869 controls were analyzed. Both case-only logistic regression analyses and polytomous logistic regression analyses (with one control set and multiple case groups) were used. Higher fruit intake was associated with a trend towards decreased risk of BRAF-mutated tumors [Odds ratio 4th vs. 1st quartile = 0.82 (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32816852
%R 10.1158/0008-5472.CAN-20-0168
%U https://inrepo02.dkfz.de/record/157617