Journal Article

DKFZ-2020-01714

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Intake of dietary fruit, vegetables, and fiber and risk of colorectal cancer according to molecular subtypes: A pooled analysis of 9 studies.

Hidaka, A. ; Harrison, T. A. ; Cao, Y. ; Sakoda, L. C. ; Barfield, R. ; Giannakis, M. ; Song, M. ; Phipps, A. I. ; Figueiredo, J. C. ; Zaidi, S. H. ; Toland, A. E. ; Amitay, E.DKFZ* ; Berndt, S. I. ; Borozan, I. ; Chan, A. T. ; Gallinger, S. ; Gunter, M. J. ; Guinter, M. A. ; Harlid, S. ; Hampel, H. ; Jenkins, M. A. ; Lin, Y. ; Moreno, V. ; Newcomb, P. A. ; Nishihara, R. ; Ogino, S. ; Obón-Santacana, M. ; Parfrey, P. S. ; Potter, J. D. ; Slattery, M. L. ; Steinfelder, R. S. ; Um, C. Y. ; Wang, X. ; Woods, M. O. ; Van Guelpen, B. ; Thibodeau, S. N. ; Hoffmeister, M.DKFZ* ; Sun, W. ; Hsu, L. ; Buchanan, D. D. ; Campbell, P. T. ; Peters, U.

2020
AACR Philadelphia, Pa.

This record in other databases:  

Please use a persistent id in citations: doi:10.1158/0008-5472.CAN-20-0168

Abstract: Protective associations of fruits, vegetables, and fiber intake with colorectal cancer (CRC) risk have been shown in many, but not all epidemiological studies. One possible reason for study heterogeneity is that dietary factors may have distinct effects by CRC molecular subtypes. Here we investigate the association of fruit, vegetables, and fiber intake with four well-established CRC molecular subtypes separately and in combination. Nine observational studies including 9,592 cases with molecular subtypes for microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and somatic mutations in BRAF and KRAS genes, and 7,869 controls were analyzed. Both case-only logistic regression analyses and polytomous logistic regression analyses (with one control set and multiple case groups) were used. Higher fruit intake was associated with a trend towards decreased risk of BRAF-mutated tumors [Odds ratio 4th vs. 1st quartile = 0.82 (95% confidence interval = 0.65-1.04)] but not BRAF-wildtype tumors [1.09 (0.97-1.22); P-difference as shown in case-only analysis = 0.02]. This difference was observed in case-control studies and not in cohort studies. Compared with controls, higher fiber intake showed negative association with CRC risk for cases with microsatellite stable (MSS)/MSI-low, CIMP-negative, BRAF-wildtype, and KRAS-wildtype tumors (Ptrend range from 0.03 to 3.4e-03), which is consistent with the traditional adenoma-CRC pathway. These negative associations were stronger compared with MSI-high, CIMP-positive, BRAF-mutated, or KRAS-mutated tumors, but the differences were not statistically significant. These inverse associations for fruit and fiber intake may explain, in part, inconsistent findings between fruit or fiber intake and CRC risk that have previously been reported.

Note: 2020 Oct 15;80(20):4578-4590

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Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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