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000157617 1001_ $$00000-0002-1772-8159$$aHidaka, Akihisa$$b0
000157617 245__ $$aIntake of dietary fruit, vegetables, and fiber and risk of colorectal cancer according to molecular subtypes: A pooled analysis of 9 studies.
000157617 260__ $$aPhiladelphia, Pa.$$bAACR$$c2020
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000157617 500__ $$a2020 Oct 15;80(20):4578-4590
000157617 520__ $$aProtective associations of fruits, vegetables, and fiber intake with colorectal cancer (CRC) risk have been shown in many, but not all epidemiological studies. One possible reason for study heterogeneity is that dietary factors may have distinct effects by CRC molecular subtypes. Here we investigate the association of fruit, vegetables, and fiber intake with four well-established CRC molecular subtypes separately and in combination. Nine observational studies including 9,592 cases with molecular subtypes for microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and somatic mutations in BRAF and KRAS genes, and 7,869 controls were analyzed. Both case-only logistic regression analyses and polytomous logistic regression analyses (with one control set and multiple case groups) were used. Higher fruit intake was associated with a trend towards decreased risk of BRAF-mutated tumors [Odds ratio 4th vs. 1st quartile = 0.82 (95% confidence interval = 0.65-1.04)] but not BRAF-wildtype tumors [1.09 (0.97-1.22); P-difference as shown in case-only analysis = 0.02]. This difference was observed in case-control studies and not in cohort studies. Compared with controls, higher fiber intake showed negative association with CRC risk for cases with microsatellite stable (MSS)/MSI-low, CIMP-negative, BRAF-wildtype, and KRAS-wildtype tumors (Ptrend range from 0.03 to 3.4e-03), which is consistent with the traditional adenoma-CRC pathway. These negative associations were stronger compared with MSI-high, CIMP-positive, BRAF-mutated, or KRAS-mutated tumors, but the differences were not statistically significant. These inverse associations for fruit and fiber intake may explain, in part, inconsistent findings between fruit or fiber intake and CRC risk that have previously been reported.
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000157617 7001_ $$00000-0002-4173-7530$$aHarrison, Tabitha A$$b1
000157617 7001_ $$aCao, Yin$$b2
000157617 7001_ $$00000-0002-0900-5735$$aSakoda, Lori C$$b3
000157617 7001_ $$aBarfield, Richard$$b4
000157617 7001_ $$aGiannakis, Marios$$b5
000157617 7001_ $$aSong, Mingyang$$b6
000157617 7001_ $$aPhipps, Amanda I$$b7
000157617 7001_ $$aFigueiredo, Jane C$$b8
000157617 7001_ $$aZaidi, Syed H$$b9
000157617 7001_ $$aToland, Amanda E$$b10
000157617 7001_ $$0P:(DE-He78)6e02c183f41e45a5867dec393fb4616a$$aAmitay, Efrat$$b11$$udkfz
000157617 7001_ $$aBerndt, Sonja I$$b12
000157617 7001_ $$aBorozan, Ivan$$b13
000157617 7001_ $$aChan, Andrew T$$b14
000157617 7001_ $$aGallinger, Steven$$b15
000157617 7001_ $$aGunter, Marc J$$b16
000157617 7001_ $$00000-0001-5547-7795$$aGuinter, Mark A$$b17
000157617 7001_ $$00000-0001-8540-6891$$aHarlid, Sophia$$b18
000157617 7001_ $$00000-0001-7558-9794$$aHampel, Heather$$b19
000157617 7001_ $$aJenkins, Mark A$$b20
000157617 7001_ $$aLin, Yi$$b21
000157617 7001_ $$00000-0002-2818-5487$$aMoreno, Victor$$b22
000157617 7001_ $$aNewcomb, Polly A$$b23
000157617 7001_ $$aNishihara, Reiko$$b24
000157617 7001_ $$00000-0002-3909-2323$$aOgino, Shuji$$b25
000157617 7001_ $$aObón-Santacana, Mireia$$b26
000157617 7001_ $$aParfrey, Patrick S$$b27
000157617 7001_ $$00000-0001-5439-1500$$aPotter, John D$$b28
000157617 7001_ $$00000-0002-1655-6543$$aSlattery, Martha L$$b29
000157617 7001_ $$aSteinfelder, Robert S$$b30
000157617 7001_ $$00000-0001-5449-6230$$aUm, Caroline Y$$b31
000157617 7001_ $$aWang, Xiaoliang$$b32
000157617 7001_ $$aWoods, Michael O$$b33
000157617 7001_ $$00000-0002-9692-101X$$aVan Guelpen, Bethany$$b34
000157617 7001_ $$aThibodeau, Stephen N$$b35
000157617 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b36$$udkfz
000157617 7001_ $$00000-0002-6350-1107$$aSun, Wei$$b37
000157617 7001_ $$aHsu, Li$$b38
000157617 7001_ $$00000-0003-2225-6675$$aBuchanan, Daniel D$$b39
000157617 7001_ $$aCampbell, Peter T$$b40
000157617 7001_ $$aPeters, Ulrike$$b41
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