TY  - JOUR
AU  - Hidaka, Akihisa
AU  - Harrison, Tabitha A
AU  - Cao, Yin
AU  - Sakoda, Lori C
AU  - Barfield, Richard
AU  - Giannakis, Marios
AU  - Song, Mingyang
AU  - Phipps, Amanda I
AU  - Figueiredo, Jane C
AU  - Zaidi, Syed H
AU  - Toland, Amanda E
AU  - Amitay, Efrat
AU  - Berndt, Sonja I
AU  - Borozan, Ivan
AU  - Chan, Andrew T
AU  - Gallinger, Steven
AU  - Gunter, Marc J
AU  - Guinter, Mark A
AU  - Harlid, Sophia
AU  - Hampel, Heather
AU  - Jenkins, Mark A
AU  - Lin, Yi
AU  - Moreno, Victor
AU  - Newcomb, Polly A
AU  - Nishihara, Reiko
AU  - Ogino, Shuji
AU  - Obón-Santacana, Mireia
AU  - Parfrey, Patrick S
AU  - Potter, John D
AU  - Slattery, Martha L
AU  - Steinfelder, Robert S
AU  - Um, Caroline Y
AU  - Wang, Xiaoliang
AU  - Woods, Michael O
AU  - Van Guelpen, Bethany
AU  - Thibodeau, Stephen N
AU  - Hoffmeister, Michael
AU  - Sun, Wei
AU  - Hsu, Li
AU  - Buchanan, Daniel D
AU  - Campbell, Peter T
AU  - Peters, Ulrike
TI  - Intake of dietary fruit, vegetables, and fiber and risk of colorectal cancer according to molecular subtypes: A pooled analysis of 9 studies.
JO  - Cancer research
VL  - 80
IS  - 20
SN  - 1538-7445
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2020-01714
SP  - 4578-4590
PY  - 2020
N1  - 2020 Oct 15;80(20):4578-4590
AB  - Protective associations of fruits, vegetables, and fiber intake with colorectal cancer (CRC) risk have been shown in many, but not all epidemiological studies. One possible reason for study heterogeneity is that dietary factors may have distinct effects by CRC molecular subtypes. Here we investigate the association of fruit, vegetables, and fiber intake with four well-established CRC molecular subtypes separately and in combination. Nine observational studies including 9,592 cases with molecular subtypes for microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and somatic mutations in BRAF and KRAS genes, and 7,869 controls were analyzed. Both case-only logistic regression analyses and polytomous logistic regression analyses (with one control set and multiple case groups) were used. Higher fruit intake was associated with a trend towards decreased risk of BRAF-mutated tumors [Odds ratio 4th vs. 1st quartile = 0.82 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:32816852
DO  - DOI:10.1158/0008-5472.CAN-20-0168
UR  - https://inrepo02.dkfz.de/record/157617
ER  -