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@ARTICLE{Hidaka:157617,
      author       = {A. Hidaka and T. A. Harrison and Y. Cao and L. C. Sakoda
                      and R. Barfield and M. Giannakis and M. Song and A. I.
                      Phipps and J. C. Figueiredo and S. H. Zaidi and A. E. Toland
                      and E. Amitay$^*$ and S. I. Berndt and I. Borozan and A. T.
                      Chan and S. Gallinger and M. J. Gunter and M. A. Guinter and
                      S. Harlid and H. Hampel and M. A. Jenkins and Y. Lin and V.
                      Moreno and P. A. Newcomb and R. Nishihara and S. Ogino and
                      M. Obón-Santacana and P. S. Parfrey and J. D. Potter and M.
                      L. Slattery and R. S. Steinfelder and C. Y. Um and X. Wang
                      and M. O. Woods and B. Van Guelpen and S. N. Thibodeau and
                      M. Hoffmeister$^*$ and W. Sun and L. Hsu and D. D. Buchanan
                      and P. T. Campbell and U. Peters},
      title        = {{I}ntake of dietary fruit, vegetables, and fiber and risk
                      of colorectal cancer according to molecular subtypes: {A}
                      pooled analysis of 9 studies.},
      journal      = {Cancer research},
      volume       = {80},
      number       = {20},
      issn         = {1538-7445},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2020-01714},
      pages        = {4578-4590},
      year         = {2020},
      note         = {2020 Oct 15;80(20):4578-4590},
      abstract     = {Protective associations of fruits, vegetables, and fiber
                      intake with colorectal cancer (CRC) risk have been shown in
                      many, but not all epidemiological studies. One possible
                      reason for study heterogeneity is that dietary factors may
                      have distinct effects by CRC molecular subtypes. Here we
                      investigate the association of fruit, vegetables, and fiber
                      intake with four well-established CRC molecular subtypes
                      separately and in combination. Nine observational studies
                      including 9,592 cases with molecular subtypes for
                      microsatellite instability (MSI), CpG island methylator
                      phenotype (CIMP), and somatic mutations in BRAF and KRAS
                      genes, and 7,869 controls were analyzed. Both case-only
                      logistic regression analyses and polytomous logistic
                      regression analyses (with one control set and multiple case
                      groups) were used. Higher fruit intake was associated with a
                      trend towards decreased risk of BRAF-mutated tumors [Odds
                      ratio 4th vs. 1st quartile = 0.82 $(95\%$ confidence
                      interval = 0.65-1.04)] but not BRAF-wildtype tumors [1.09
                      (0.97-1.22); P-difference as shown in case-only analysis =
                      0.02]. This difference was observed in case-control studies
                      and not in cohort studies. Compared with controls, higher
                      fiber intake showed negative association with CRC risk for
                      cases with microsatellite stable (MSS)/MSI-low,
                      CIMP-negative, BRAF-wildtype, and KRAS-wildtype tumors
                      (Ptrend range from 0.03 to 3.4e-03), which is consistent
                      with the traditional adenoma-CRC pathway. These negative
                      associations were stronger compared with MSI-high,
                      CIMP-positive, BRAF-mutated, or KRAS-mutated tumors, but the
                      differences were not statistically significant. These
                      inverse associations for fruit and fiber intake may explain,
                      in part, inconsistent findings between fruit or fiber intake
                      and CRC risk that have previously been reported.},
      cin          = {C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32816852},
      doi          = {10.1158/0008-5472.CAN-20-0168},
      url          = {https://inrepo02.dkfz.de/record/157617},
}