TY  - JOUR
AU  - Ose, Jennifer
AU  - Holowatyj, Andreana N
AU  - Nattenmüller, Johanna
AU  - Gigic, Biljana
AU  - Lin, Tengda
AU  - Himbert, Caroline
AU  - Habermann, Nina
AU  - Achaintre, David
AU  - Scalbert, Augustin
AU  - Keski-Rahkonen, Pekka
AU  - Böhm, Jürgen
AU  - Schrotz-King, Petra
AU  - Schneider, Martin
AU  - Ulrich, Alexis
AU  - Kampman, Ellen
AU  - Weijenberg, Matty
AU  - Gsur, Andrea
AU  - Ueland, Per-Magne
AU  - Kauczor, Hans-Ulrich
AU  - Ulrich, Cornelia M
TI  - Metabolomics profiling of visceral and abdominal subcutaneous adipose tissue in colorectal cancer patients: results from the ColoCare study.
JO  - Cancer causes & control
VL  - 31
IS  - 8
SN  - 1573-7225
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V.
M1  - DKFZ-2020-01791
SP  - 723 - 735
PY  - 2020
AB  - Underlying mechanisms of the relationship between body fatness and colorectal cancer remain unclear. This study investigated associations of circulating metabolites with visceral (VFA), abdominal subcutaneous (SFA), and total fat area (TFA) in colorectal cancer patients.Pre-surgery plasma samples from 212 patients (stage I-IV) from the ColoCare Study were used to perform targeted metabolomics. VFA, SFA, and TFA were quantified by computed tomography scans. Partial correlation and linear regression analyses of VFA, SFA, and TFA with metabolites were computed and corrected for multiple testing. Cox proportional hazards were used to assess 2-year survival.In patients with metastatic tumors, SFA and TFA were statistically significantly inversely associated with 16 glycerophospholipids (SFA: pFDR range 0.017-0.049; TFA: pFDR range 0.029-0.048), while VFA was not. Doubling of ten of the aforementioned glycerophospholipids was associated with increased risk of death in patients with metastatic tumors, but not in patients with non-metastatic tumors (phet range: 0.00044-0.049). Doubling of PC ae C34:0 was associated with ninefold increased risk of death in metastatic tumors (Hazard Ratio [HR], 9.05; 95
KW  - Adiposity
KW  - Adolescent
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Body Mass Index
KW  - Colorectal Neoplasms: diagnostic imaging
KW  - Colorectal Neoplasms: metabolism
KW  - Colorectal Neoplasms: pathology
KW  - Female
KW  - Humans
KW  - Intra-Abdominal Fat: diagnostic imaging
KW  - Intra-Abdominal Fat: metabolism
KW  - Male
KW  - Metabolomics
KW  - Middle Aged
KW  - Neoplasm Staging
KW  - Subcutaneous Fat, Abdominal: diagnostic imaging
KW  - Subcutaneous Fat, Abdominal: metabolism
KW  - Tomography, X-Ray Computed
KW  - Young Adult
LB  - PUB:(DE-HGF)16
C6  - pmid:32430684
C2  - pmc:PMC7425810
DO  - DOI:10.1007/s10552-020-01312-1
UR  - https://inrepo02.dkfz.de/record/157754
ER  -