Journal Article

DKFZ-2020-01791

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Metabolomics profiling of visceral and abdominal subcutaneous adipose tissue in colorectal cancer patients: results from the ColoCare study.

Ose, J. ; Holowatyj, A. N. ; Nattenmüller, J. ; Gigic, B. ; Lin, T. ; Himbert, C. ; Habermann, N. ; Achaintre, D. ; Scalbert, A. ; Keski-Rahkonen, P. ; Böhm, J. ; Schrotz-King, P.DKFZ* ; Schneider, M. ; Ulrich, A. ; Kampman, E. ; Weijenberg, M. ; Gsur, A. ; Ueland, P.-M. ; Kauczor, H.-U. ; Ulrich, C. M.

2020
Springer Science + Business Media B.V. Dordrecht [u.a.]

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Please use a persistent id in citations: doi:10.1007/s10552-020-01312-1

Abstract: Underlying mechanisms of the relationship between body fatness and colorectal cancer remain unclear. This study investigated associations of circulating metabolites with visceral (VFA), abdominal subcutaneous (SFA), and total fat area (TFA) in colorectal cancer patients.Pre-surgery plasma samples from 212 patients (stage I-IV) from the ColoCare Study were used to perform targeted metabolomics. VFA, SFA, and TFA were quantified by computed tomography scans. Partial correlation and linear regression analyses of VFA, SFA, and TFA with metabolites were computed and corrected for multiple testing. Cox proportional hazards were used to assess 2-year survival.In patients with metastatic tumors, SFA and TFA were statistically significantly inversely associated with 16 glycerophospholipids (SFA: pFDR range 0.017-0.049; TFA: pFDR range 0.029-0.048), while VFA was not. Doubling of ten of the aforementioned glycerophospholipids was associated with increased risk of death in patients with metastatic tumors, but not in patients with non-metastatic tumors (phet range: 0.00044-0.049). Doubling of PC ae C34:0 was associated with ninefold increased risk of death in metastatic tumors (Hazard Ratio [HR], 9.05; 95% confidence interval [CI] 2.17-37.80); an inverse association was observed in non-metastatic tumors (HR 0.17; 95% CI 0.04-0.87; phet = 0.00044).These data provide initial evidence that glycerophospholipids in metastatic colorectal cancer are uniquely associated with subcutaneous adiposity, and may impact overall survival.

Keyword(s): Adiposity (MeSH) ; Adolescent (MeSH) ; Adult (MeSH) ; Aged (MeSH) ; Aged, 80 and over (MeSH) ; Body Mass Index (MeSH) ; Colorectal Neoplasms: diagnostic imaging (MeSH) ; Colorectal Neoplasms: metabolism (MeSH) ; Colorectal Neoplasms: pathology (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Intra-Abdominal Fat: diagnostic imaging (MeSH) ; Intra-Abdominal Fat: metabolism (MeSH) ; Male (MeSH) ; Metabolomics (MeSH) ; Middle Aged (MeSH) ; Neoplasm Staging (MeSH) ; Subcutaneous Fat, Abdominal: diagnostic imaging (MeSH) ; Subcutaneous Fat, Abdominal: metabolism (MeSH) ; Tomography, X-Ray Computed (MeSH) ; Young Adult (MeSH)

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Contributing Institute(s):

1. Präventive Onkologie (C120)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Springer ; Essential Science Indicators ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; National-Konsortium ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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