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@ARTICLE{Ose:157754,
      author       = {J. Ose and A. N. Holowatyj and J. Nattenmüller and B.
                      Gigic and T. Lin and C. Himbert and N. Habermann and D.
                      Achaintre and A. Scalbert and P. Keski-Rahkonen and J. Böhm
                      and P. Schrotz-King$^*$ and M. Schneider and A. Ulrich and
                      E. Kampman and M. Weijenberg and A. Gsur and P.-M. Ueland
                      and H.-U. Kauczor and C. M. Ulrich},
      title        = {{M}etabolomics profiling of visceral and abdominal
                      subcutaneous adipose tissue in colorectal cancer patients:
                      results from the {C}olo{C}are study.},
      journal      = {Cancer causes $\&$ control},
      volume       = {31},
      number       = {8},
      issn         = {1573-7225},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {DKFZ-2020-01791},
      pages        = {723 - 735},
      year         = {2020},
      abstract     = {Underlying mechanisms of the relationship between body
                      fatness and colorectal cancer remain unclear. This study
                      investigated associations of circulating metabolites with
                      visceral (VFA), abdominal subcutaneous (SFA), and total fat
                      area (TFA) in colorectal cancer patients.Pre-surgery plasma
                      samples from 212 patients (stage I-IV) from the ColoCare
                      Study were used to perform targeted metabolomics. VFA, SFA,
                      and TFA were quantified by computed tomography scans.
                      Partial correlation and linear regression analyses of VFA,
                      SFA, and TFA with metabolites were computed and corrected
                      for multiple testing. Cox proportional hazards were used to
                      assess 2-year survival.In patients with metastatic tumors,
                      SFA and TFA were statistically significantly inversely
                      associated with 16 glycerophospholipids (SFA: pFDR range
                      0.017-0.049; TFA: pFDR range 0.029-0.048), while VFA was
                      not. Doubling of ten of the aforementioned
                      glycerophospholipids was associated with increased risk of
                      death in patients with metastatic tumors, but not in
                      patients with non-metastatic tumors (phet range:
                      0.00044-0.049). Doubling of PC ae C34:0 was associated with
                      ninefold increased risk of death in metastatic tumors
                      (Hazard Ratio [HR], 9.05; $95\%$ confidence interval [CI]
                      2.17-37.80); an inverse association was observed in
                      non-metastatic tumors (HR 0.17; $95\%$ CI 0.04-0.87;
                      phet = 0.00044).These data provide initial evidence that
                      glycerophospholipids in metastatic colorectal cancer are
                      uniquely associated with subcutaneous adiposity, and may
                      impact overall survival.},
      keywords     = {Adiposity / Adolescent / Adult / Aged / Aged, 80 and over /
                      Body Mass Index / Colorectal Neoplasms: diagnostic imaging /
                      Colorectal Neoplasms: metabolism / Colorectal Neoplasms:
                      pathology / Female / Humans / Intra-Abdominal Fat:
                      diagnostic imaging / Intra-Abdominal Fat: metabolism / Male
                      / Metabolomics / Middle Aged / Neoplasm Staging /
                      Subcutaneous Fat, Abdominal: diagnostic imaging /
                      Subcutaneous Fat, Abdominal: metabolism / Tomography, X-Ray
                      Computed / Young Adult},
      cin          = {C120},
      ddc          = {610},
      cid          = {I:(DE-He78)C120-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32430684},
      pmc          = {pmc:PMC7425810},
      doi          = {10.1007/s10552-020-01312-1},
      url          = {https://inrepo02.dkfz.de/record/157754},
}