%0 Journal Article
%A Kramer, Iris
%A Hooning, Maartje J
%A Mavaddat, Nasim
%A Hauptmann, Michael
%A Keeman, Renske
%A Steyerberg, Ewout W
%A Giardiello, Daniele
%A Antoniou, Antonis C
%A Pharoah, Paul D P
%A Canisius, Sander
%A Abu-Ful, Zumuruda
%A Andrulis, Irene L
%A Anton-Culver, Hoda
%A Aronson, Kristan J
%A Augustinsson, Annelie
%A Becher, Heiko
%A Beckmann, Matthias W
%A Behrens, Sabine
%A Benitez, Javier
%A Bermisheva, Marina
%A Bogdanova, Natalia V
%A Bojesen, Stig E
%A Bolla, Manjeet K
%A Bonanni, Bernardo
%A Brauch, Hiltrud
%A Bremer, Michael
%A Brucker, Sara Y
%A Burwinkel, Barbara
%A Castelao, Jose E
%A Chan, Tsun L
%A Chang-Claude, Jenny
%A Chanock, Stephen J
%A Chenevix-Trench, Georgia
%A Choi, Ji-Yeob
%A Clarke, Christine L
%A Collée, J Margriet
%A Couch, Fergus J
%A Cox, Angela
%A Cross, Simon S
%A Czene, Kamila
%A Daly, Mary B
%A Devilee, Peter
%A Dörk, Thilo
%A Dos-Santos-Silva, Isabel
%A Dunning, Alison M
%A Dwek, Miriam
%A Eccles, Diana M
%A Evans, D Gareth
%A Fasching, Peter A
%A Flyger, Henrik
%A Gago-Dominguez, Manuela
%A García-Closas, Montserrat
%A García-Sáenz, José A
%A Giles, Graham G
%A Goldgar, David E
%A González-Neira, Anna
%A Haiman, Christopher A
%A Håkansson, Niclas
%A Hamann, Ute
%A Hartman, Mikael
%A Heemskerk-Gerritsen, Bernadette A M
%A Hollestelle, Antoinette
%A Hopper, John L
%A Hou, Ming-Feng
%A Howell, Anthony
%A Ito, Hidemi
%A Jakimovska, Milena
%A Jakubowska, Anna
%A Janni, Wolfgang
%A John, Esther M
%A Jung, Audrey
%A Kang, Daehee
%A Kets, C Marleen
%A Khusnutdinova, Elza
%A Ko, Yon-Dschun
%A Kristensen, Vessela N
%A Kurian, Allison W
%A Kwong, Ava
%A Lambrechts, Diether
%A Le Marchand, Loic
%A Li, Jingmei
%A Lindblom, Annika
%A Lubiński, Jan
%A Mannermaa, Arto
%A Manoochehri, Mehdi
%A Margolin, Sara
%A Matsuo, Keitaro
%A Mavroudis, Dimitrios
%A Meindl, Alfons
%A Milne, Roger L
%A Mulligan, Anna Marie
%A Muranen, Taru A
%A Neuhausen, Susan L
%A Nevanlinna, Heli
%A Newman, William G
%A Olshan, Andrew F
%A Olson, Janet E
%A Olsson, Håkan
%A Park-Simon, Tjoung-Won
%A Peto, Julian
%A Petridis, Christos
%A Plaseska-Karanfilska, Dijana
%A Presneau, Nadege
%A Pylkäs, Katri
%A Radice, Paolo
%A Rennert, Gad
%A Romero, Atocha
%A Roylance, Rebecca
%A Saloustros, Emmanouil
%A Sawyer, Elinor J
%A Schmutzler, Rita K
%A Schwentner, Lukas
%A Scott, Christopher
%A See, Mee-Hoong
%A Shah, Mitul
%A Shen, Chen-Yang
%A Shu, Xiao-Ou
%A Siesling, Sabine
%A Slager, Susan
%A Sohn, Christof
%A Southey, Melissa C
%A Spinelli, John J
%A Stone, Jennifer
%A Tapper, William J
%A Tengström, Maria
%A Teo, Soo Hwang
%A Terry, Mary Beth
%A Tollenaar, Rob A E M
%A Tomlinson, Ian
%A Troester, Melissa A
%A Vachon, Celine M
%A van Ongeval, Chantal
%A van Veen, Elke M
%A Winqvist, Robert
%A Wolk, Alicja
%A Zheng, Wei
%A Ziogas, Argyrios
%A Easton, Douglas F
%A Hall, Per
%A Schmidt, Marjanka K
%A Børresen-Dale, Anne-Lise
%A Sahlberg, Kristine
%A Ottestad, Lars
%A Kåresen, Rolf
%A Schlichting, Ellen
%A Holmen, Marit Muri
%A Sauer, Toril
%A Haakensen, Vilde
%A Engebråten, Olav
%A Naume, Bjørn
%A Fosså, Alexander
%A Kiserud, Cecile
%A Reinertsen, Kristin
%A Helland, Åslaug
%A Riis, Margit
%A Geisler, Jürgen
%A Alnæs, Grethe Grenaker
%A Clarke, Christine
%A Marsh, Deborah
%A Scott, Rodney
%A Baxter, Robert
%A Yip, Desmond
%A Carpenter, Jane
%A Davis, Alison
%A Pathmanathan, Nirmala
%A Simpson, Peter
%A Graham, J Dinny
%A Sachchithananthan, Mythily
%A Amor, David
%A Andrews, Lesley
%A Antill, Yoland
%A Balleine, Rosemary
%A Beesley, Jonathan
%A Bennett, Ian
%A Bogwitz, Michael
%A Botes, Leon
%A Brennan, Meagan
%A Brown, Melissa
%A Buckley, Michael
%A Burke, Jo
%A Butow, Phyllis
%A Caldon, Liz
%A Campbell, Ian
%A Chauhan, Deepa
%A Chauhan, Manisha
%A Chenevix-Trench, Georgia
%A Christian, Alice
%A Cohen, Paul
%A Colley, Alison
%A Crook, Ashley
%A Cui, James
%A Cummings, Margaret
%A Dawson, Sarah-Jane
%A deFazio, Anna
%A Delatycki, Martin
%A Dickson, Rebecca
%A Dixon, Joanne
%A Edkins, Ted
%A Edwards, Stacey
%A Farshid, Gelareh
%A Fellows, Andrew
%A Fenton, Georgina
%A Field, Michael
%A Flanagan, James
%A Fong, Peter
%A Forrest, Laura
%A Fox, Stephen
%A French, Juliet
%A Friedlander, Michael
%A Gaff, Clara
%A Gattas, Mike
%A George, Peter
%A Greening, Sian
%A Harris, Marion
%A Hart, Stewart
%A Hayward, Nick
%A Hopper, John
%A Hoskins, Cass
%A Hunt, Clare
%A James, Paul
%A Jenkins, Mark
%A Kidd, Alexa
%A Kirk, Judy
%A Koehler, Jessica
%A Kollias, James
%A Lakhani, Sunil
%A Lawrence, Mitchell
%A Lindeman, Geoff
%A Lipton, Lara
%A Lobb, Liz
%A Mann, Graham
%A Marsh, Deborah
%A McLachlan, Sue Anne
%A Meiser, Bettina
%A Milne, Roger
%A Nightingale, Sophie
%A O'Connell, Shona
%A O'Sullivan, Sarah
%A Ortega, David Gallego
%A Pachter, Nick
%A Patterson, Briony
%A Pearn, Amy
%A Phillips, Kelly
%A Pieper, Ellen
%A Rickard, Edwina
%A Robinson, Bridget
%A Saleh, Mona
%A Salisbury, Elizabeth
%A Saunders, Christobel
%A Saunus, Jodi
%A Scott, Rodney
%A Scott, Clare
%A Sexton, Adrienne
%A Shelling, Andrew
%A Simpson, Peter
%A Southey, Melissa
%A Spurdle, Amanda
%A Taylor, Jessica
%A Taylor, Renea
%A Thorne, Heather
%A Trainer, Alison
%A Tucker, Kathy
%A Visvader, Jane
%A Walker, Logan
%A Williams, Rachael
%A Winship, Ingrid
%A Young, Mary Ann
%T Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk.
%J The American journal of human genetics
%V 107
%N 5
%@ 0002-9297
%C New York, NY
%I Elsevier
%M DKFZ-2020-02143
%P 837-848
%D 2020
%Z 2020 Nov 5;107(5):837-848
%X Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing primary invasive breast cancer. This study aimed to evaluate the association between a recently validated PRS of 313 germline variants (PRS313) and contralateral breast cancer (CBC) risk. We included 56,068 women of European ancestry diagnosed with first invasive breast cancer from 1990 onward with follow-up from the Breast Cancer Association Consortium. Metachronous CBC risk (N = 1,027) according to the distribution of PRS313 was quantified using Cox regression analyses. We assessed PRS313 interaction with age at first diagnosis, family history, morphology, ER status, PR status, and HER2 status, and (neo)adjuvant therapy. In studies of Asian women, with limited follow-up, CBC risk associated with PRS313 was assessed using logistic regression for 340 women with CBC compared with 12,133 women with unilateral breast cancer. Higher PRS313 was associated with increased CBC risk: hazard ratio per standard deviation (SD) = 1.25 (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33022221
%R 10.1016/j.ajhg.2020.09.001
%U https://inrepo02.dkfz.de/record/163919