Journal Article (Review Article) DKFZ-2020-02168

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential.

 ;  ;  ;  ;  ;  ;  ;  ;

2020
Macmillan Publishers, part of Springer Nature London

Signal transduction and targeted therapy 5(1), 227 () [10.1038/s41392-020-00311-7]
 GO

This record in other databases:  

Please use a persistent id in citations: doi:

Abstract: Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells to adapt to environmental changes including nutrient perturbation, genotoxic factors, circadian disorder, infection, inflammation and xenobiotics. These effects are mainly achieved by the driving effect of NAD+ on metabolic pathways as enzyme cofactors transferring hydrogen in oxidation-reduction reactions. Besides, multiple NAD+-dependent enzymes are involved in physiology either by post-synthesis chemical modification of DNA, RNA and proteins, or releasing second messenger cyclic ADP-ribose (cADPR) and NAADP+. Prolonged disequilibrium of NAD+ metabolism disturbs the physiological functions, resulting in diseases including metabolic diseases, cancer, aging and neurodegeneration disorder. In this review, we summarize recent advances in our understanding of the molecular mechanisms of NAD+-regulated physiological responses to stresses, the contribution of NAD+ deficiency to various diseases via manipulating cellular communication networks and the potential new avenues for therapeutic intervention.

Classification:

Note: #LA:E055#

Contributing Institute(s):
  1. E055 KKE Translationale Radioonkologie (E055)
Research Program(s):
  1. 315 - Imaging and radiooncology (POF3-315) (POF3-315)

Appears in the scientific report 2020
Database coverage:
Medline ; Creative Commons Attribution CC BY (No Version) ; DOAJ ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; Science Citation Index Expanded ; Web of Science Core Collection
Click to display QR Code for this record

The record appears in these collections:
Document types > Articles > Journal Article
Public records
Publications database

 Record created 2020-10-12, last modified 2024-02-29


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)