Journal Article (Review Article)

DKFZ-2020-02194

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png De-escalation concepts for chemoradiotherapy of HPV-positive oropharyngeal carcinomas: pros and cons[Deeskalationsstrategien für die Radiochemotherapie HPV-positiver Oropharynxkarzinome: Pro und Kontra].

Rühle, A. (First author)DKFZ* ; Nicolay, N. H. (Last author)DKFZ*

2021
Springer New York

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Please use a persistent id in citations: doi:10.1007/s00106-020-00955-5

Abstract: In contrast to alcohol- and nicotine-induced head and neck tumors, human papillomavirus (HPV)-positive oropharyngeal carcinoma rather affects younger patients, and the incidence of this entity is continuously increasing. Due to the significantly better prognosis of HPV-positive oropharyngeal carcinoma, various treatment de-escalation strategies are currently being investigated, with the aim of reducing toxicity without affecting the good survival rates of these patients.This study aims to evaluate the evidence for treatment de-escalation in HPV-positive oropharyngeal carcinoma.A literature search was performed and relevant studies are critically discussed.De-escalation strategies for HPV-associated oropharyngeal carcinoma using induction chemotherapy or radiation dose reduction have demonstrated good oncological results in phase II trials, with lower toxicity rates compared to historical controls. However, both of the first published phase III trials investigating de-escalation of concomitant chemotherapy regimens demonstrated inferior outcomes for the deescalated treatment strategies without improvements in treatment-associated toxicities. Additional phase-III trials investigating other de-escalation strategies have not yet been published.Treatment de-escalation should be performed exclusively in prospective studies and can currently not be recommended in clinical routine.

Note: 2021 Apr;69(4):278-284

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Contributing Institute(s):

1. DKTK FR zentral (FR01)
2. E055 KKE Molekulare Radioonkologie (E055)

Research Program(s):

1. 315 - Bildgebung und Radioonkologie (POF4-315) (POF4-315)

Appears in the scientific report 2021

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Springer ; Essential Science Indicators ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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