Journal Article

DKFZ-2020-02269

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Common Mechanistic Pathways in Cancer and Heart Failure.

de Boer, R. A. ; Hulot, J.-S. ; Gabriele Tocchetti, C. ; Aboumsallem, J. P. ; Ameri, P. ; Anker, S. D. ; Bauersachs, J. ; Bertero, E. ; Coats, A. A. J. ; Čelutkienė, J. ; Chioncel, O. ; Dodion, P. ; Eschenhagen, T. ; Farmakis, D. ; Bayes-Genis, A. ; Jäger, D. ; Jankowska, E. A. ; Kitsis, R. N. ; Konety, S. H. ; Larkin, J. ; Lehmann, L.DKFZ* ; Lenihan, D. J. ; Maack, C. ; Moslehi, J. ; Müller, O. J. ; Nowak-Sliwinska, P. ; Piepoli, M. F. ; Ponikowski, P. ; Pudil, R. ; Rainer, P. P. ; Ruschitzka, F. ; Sawyer, D. ; Seferovic, P. M. ; Suter, T. ; Thum, T. ; van der Meer, P. ; Van Laake, L. W. ; von Haehling, S. ; Heymans, S. ; Lyon, A. R. ; Backs, J.

2020
Wiley Oxford

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Please use a persistent id in citations: doi:10.1002/ejhf.2029

Abstract: The co-occurrence of cancer and heart failure (HF) represents a significant clinical drawback as each disease interferes with the treatment of the other. In addition to shared risk factors, a growing body of experimental and clinical evidence reveals numerous commonalities in the biology underlying both pathologies. Inflammation emerges as a common hallmark for both diseases as it contributes to the initiation, and progression of both HF and cancer. Under stress, malignant and cardiac cells change their metabolic preferences to survive, which makes these metabolic derangements a great basis to develop intersection strategies and therapies to combat both diseases. Further, genetic predisposition and clonal hematopoiesis are common drivers for both conditions and they hold great clinical relevance in the context of personalized medicine. Also, altered angiogenesis is a common hallmark for failing hearts and tumors and represents a promising substrate to target in both diseases. Cardiac cells and malignant cells interact with their surrounding environment called stroma. This interaction mediates the progression of the 2 pathologies and understanding the structure and function of each stromal component may pave the way for innovative therapeutic strategies and improved outcomes in patients. The interdisciplinary collaboration between cardiologists and oncologists is essential to establish unified guidelines. Also, preclinical models that mimic the human situation, where both pathologies coexist, are needed to understand all the aspects of the bidirectional relationship between cancer and HF. Finally, adequately powered clinical studies, including all ages, and men and women, with proper adjudication of both cancer and CV end points, are essential to accurately study these two pathologies at the same time.

Note: 2020 Dec;22(12):2272-2289

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Contributing Institute(s):

1. AD Cardio Oncology (G834)

Research Program(s):

1. 319H - Addenda (POF3-319H) (POF3-319H)

Appears in the scientific report 2020

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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