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000164200 0247_ $$2doi$$a10.1007/s10654-019-00559-6
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000164200 0247_ $$2ISSN$$a1573-7284
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000164200 1001_ $$00000-0003-1049-6225$$aNaudin, Sabine$$b0
000164200 245__ $$aHealthy lifestyle and the risk of pancreatic cancer in the EPIC study.
000164200 260__ $$aDordrecht [u.a.]$$bSpringer Science + Business Media B.V.$$c2020
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000164200 520__ $$aPancreatic cancer (PC) is a highly fatal cancer with currently limited opportunities for early detection and effective treatment. Modifiable factors may offer pathways for primary prevention. In this study, the association between the Healthy Lifestyle Index (HLI) and PC risk was examined. Within the European Prospective Investigation into Cancer and Nutrition cohort, 1113 incident PC (57% women) were diagnosed from 400,577 participants followed-up for 15 years (median). HLI scores combined smoking, alcohol intake, dietary exposure, physical activity and, in turn, overall and central adiposity using BMI (HLIBMI) and waist-to-hip ratio (WHR, HLIWHR), respectively. High values of HLI indicate adherence to healthy behaviors. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and 95% confidence intervals (CI). Sensitivity analyses were performed by excluding, in turn, each factor from the HLI score. Population attributable fractions (PAF) were estimated assuming participants' shift to healthier lifestyles. The HRs for a one-standard deviation increment of HLIBMI and HLIWHR were 0.84 (95% CI: 0.79, 0.89; ptrend = 4.3e-09) and 0.77 (0.72, 0.82; ptrend = 1.7e-15), respectively. Exclusions of smoking from HLIWHR resulted in HRs of 0.88 (0.82, 0.94; ptrend = 4.9e-04). The overall PAF estimate was 19% (95% CI: 11%, 26%), and 14% (6%, 21%) when smoking was removed from the score. Adherence to a healthy lifestyle was inversely associated with PC risk, beyond the beneficial role of smoking avoidance. Public health measures targeting compliance with healthy lifestyles may have an impact on PC incidence.
000164200 536__ $$0G:(DE-HGF)POF3-313$$a313 - Cancer risk factors and prevention (POF3-313)$$cPOF3-313$$fPOF III$$x0
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000164200 650_2 $$2MeSH$$aAlcohol Drinking: epidemiology
000164200 650_2 $$2MeSH$$aCohort Studies
000164200 650_2 $$2MeSH$$aExercise
000164200 650_2 $$2MeSH$$aFemale
000164200 650_2 $$2MeSH$$aHealthy Lifestyle
000164200 650_2 $$2MeSH$$aHumans
000164200 650_2 $$2MeSH$$aIncidence
000164200 650_2 $$2MeSH$$aMale
000164200 650_2 $$2MeSH$$aNutritional Status
000164200 650_2 $$2MeSH$$aObesity: complications
000164200 650_2 $$2MeSH$$aObesity, Abdominal: complications
000164200 650_2 $$2MeSH$$aObesity, Abdominal: epidemiology
000164200 650_2 $$2MeSH$$aPancreatic Neoplasms: epidemiology
000164200 650_2 $$2MeSH$$aPancreatic Neoplasms: etiology
000164200 650_2 $$2MeSH$$aProportional Hazards Models
000164200 650_2 $$2MeSH$$aProspective Studies
000164200 650_2 $$2MeSH$$aRisk Factors
000164200 650_2 $$2MeSH$$aSmoking: epidemiology
000164200 650_2 $$2MeSH$$aWaist-Hip Ratio
000164200 7001_ $$aViallon, Vivian$$b1
000164200 7001_ $$aHashim, Dana$$b2
000164200 7001_ $$aFreisling, Heinz$$b3
000164200 7001_ $$aJenab, Mazda$$b4
000164200 7001_ $$aWeiderpass, Elisabete$$b5
000164200 7001_ $$aPerrier, Flavie$$b6
000164200 7001_ $$aMcKenzie, Fiona$$b7
000164200 7001_ $$aBueno-de-Mesquita, H Bas$$b8
000164200 7001_ $$aOlsen, Anja$$b9
000164200 7001_ $$aTjønneland, Anne$$b10
000164200 7001_ $$aDahm, Christina C$$b11
000164200 7001_ $$aOvervad, Kim$$b12
000164200 7001_ $$aMancini, Francesca R$$b13
000164200 7001_ $$aRebours, Vinciane$$b14
000164200 7001_ $$aBoutron-Ruault, Marie-Christine$$b15
000164200 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b16$$udkfz
000164200 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b17$$udkfz
000164200 7001_ $$aBergmann, Manuela$$b18
000164200 7001_ $$aBoeing, Heiner$$b19
000164200 7001_ $$aPeppa, Eleni$$b20
000164200 7001_ $$aKarakatsani, Anna$$b21
000164200 7001_ $$aTrichopoulou, Antonia$$b22
000164200 7001_ $$aPala, Valeria$$b23
000164200 7001_ $$aMasala, Giovana$$b24
000164200 7001_ $$aPanico, Salvatore$$b25
000164200 7001_ $$aTumino, Rosario$$b26
000164200 7001_ $$aSacerdote, Carlotta$$b27
000164200 7001_ $$aMay, Anne M$$b28
000164200 7001_ $$avan Gils, Carla H$$b29
000164200 7001_ $$aRylander, Charlotta$$b30
000164200 7001_ $$aBorch, Kristin Benjaminsen$$b31
000164200 7001_ $$aChirlaque López, María Dolores$$b32
000164200 7001_ $$aSánchez, Maria-Jose$$b33
000164200 7001_ $$aArdanaz, Eva$$b34
000164200 7001_ $$aQuirós, José Ramón$$b35
000164200 7001_ $$aAmiano Exezarreta, Pilar$$b36
000164200 7001_ $$aSund, Malin$$b37
000164200 7001_ $$aDrake, Isabel$$b38
000164200 7001_ $$aRegnér, Sara$$b39
000164200 7001_ $$aTravis, Ruth C$$b40
000164200 7001_ $$aWareham, Nick$$b41
000164200 7001_ $$aAune, Dagfinn$$b42
000164200 7001_ $$aRiboli, Elio$$b43
000164200 7001_ $$aGunter, Marc J$$b44
000164200 7001_ $$aDuell, Eric J$$b45
000164200 7001_ $$aBrennan, Paul$$b46
000164200 7001_ $$aFerrari, Pietro$$b47
000164200 773__ $$0PERI:(DE-600)2004992-4$$a10.1007/s10654-019-00559-6$$gVol. 35, no. 10, p. 975 - 986$$n10$$p975 - 986$$tEuropean journal of epidemiology$$v35$$x1573-7284$$y2020
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