Journal Article

DKFZ-2020-02310

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Healthy lifestyle and the risk of pancreatic cancer in the EPIC study.

Naudin, S. ; Viallon, V. ; Hashim, D. ; Freisling, H. ; Jenab, M. ; Weiderpass, E. ; Perrier, F. ; McKenzie, F. ; Bueno-de-Mesquita, H. B. ; Olsen, A. ; Tjønneland, A. ; Dahm, C. C. ; Overvad, K. ; Mancini, F. R. ; Rebours, V. ; Boutron-Ruault, M.-C. ; Katzke, V.DKFZ* ; Kaaks, R.DKFZ* ; Bergmann, M. ; Boeing, H. ; Peppa, E. ; Karakatsani, A. ; Trichopoulou, A. ; Pala, V. ; Masala, G. ; Panico, S. ; Tumino, R. ; Sacerdote, C. ; May, A. M. ; van Gils, C. H. ; Rylander, C. ; Borch, K. B. ; Chirlaque López, M. D. ; Sánchez, M.-J. ; Ardanaz, E. ; Quirós, J. R. ; Amiano Exezarreta, P. ; Sund, M. ; Drake, I. ; Regnér, S. ; Travis, R. C. ; Wareham, N. ; Aune, D. ; Riboli, E. ; Gunter, M. J. ; Duell, E. J. ; Brennan, P. ; Ferrari, P.

2020
Springer Science + Business Media B.V. Dordrecht [u.a.]

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Please use a persistent id in citations: doi:10.1007/s10654-019-00559-6

Abstract: Pancreatic cancer (PC) is a highly fatal cancer with currently limited opportunities for early detection and effective treatment. Modifiable factors may offer pathways for primary prevention. In this study, the association between the Healthy Lifestyle Index (HLI) and PC risk was examined. Within the European Prospective Investigation into Cancer and Nutrition cohort, 1113 incident PC (57% women) were diagnosed from 400,577 participants followed-up for 15 years (median). HLI scores combined smoking, alcohol intake, dietary exposure, physical activity and, in turn, overall and central adiposity using BMI (HLIBMI) and waist-to-hip ratio (WHR, HLIWHR), respectively. High values of HLI indicate adherence to healthy behaviors. Cox proportional hazard models with age as primary time variable were used to estimate PC hazard ratios (HR) and 95% confidence intervals (CI). Sensitivity analyses were performed by excluding, in turn, each factor from the HLI score. Population attributable fractions (PAF) were estimated assuming participants' shift to healthier lifestyles. The HRs for a one-standard deviation increment of HLIBMI and HLIWHR were 0.84 (95% CI: 0.79, 0.89; ptrend = 4.3e-09) and 0.77 (0.72, 0.82; ptrend = 1.7e-15), respectively. Exclusions of smoking from HLIWHR resulted in HRs of 0.88 (0.82, 0.94; ptrend = 4.9e-04). The overall PAF estimate was 19% (95% CI: 11%, 26%), and 14% (6%, 21%) when smoking was removed from the score. Adherence to a healthy lifestyle was inversely associated with PC risk, beyond the beneficial role of smoking avoidance. Public health measures targeting compliance with healthy lifestyles may have an impact on PC incidence.

Keyword(s): Alcohol Drinking: epidemiology (MeSH) ; Cohort Studies (MeSH) ; Exercise (MeSH) ; Female (MeSH) ; Healthy Lifestyle (MeSH) ; Humans (MeSH) ; Incidence (MeSH) ; Male (MeSH) ; Nutritional Status (MeSH) ; Obesity: complications (MeSH) ; Obesity, Abdominal: complications (MeSH) ; Obesity, Abdominal: epidemiology (MeSH) ; Pancreatic Neoplasms: epidemiology (MeSH) ; Pancreatic Neoplasms: etiology (MeSH) ; Proportional Hazards Models (MeSH) ; Prospective Studies (MeSH) ; Risk Factors (MeSH) ; Smoking: epidemiology (MeSH) ; Waist-Hip Ratio (MeSH)

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Springer ; Essential Science Indicators ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; National-Konsortium ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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