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@ARTICLE{SaberiHosnijeh:164247,
      author       = {F. Saberi Hosnijeh and D. Casabonne and A. Nieters and M.
                      Solans and S. Naudin and P. Ferrari and J. D. Mckay and Y.
                      Benavente and E. Weiderpass and H. Freisling and G. Severi
                      and M.-C. Boutron Ruault and C. Besson and C. Agnoli and G.
                      Masala and C. Sacerdote and R. Tumino and J. M. Huerta and
                      P. Amiano and M. Rodriguez-Barranco and C. Bonet and A.
                      Barricarte and S. Christakoudi and A. Knuppel and B.
                      Bueno-de-Mesquita and M. B. Schulze and R. Kaaks$^*$ and F.
                      Canzian$^*$ and F. Späth and M. Jerkeman and C. Rylander
                      and A. Tjønneland and A. Olsen and K. B. Borch and R.
                      Vermeulen},
      title        = {{A}ssociation between anthropometry and lifestyle factors
                      and risk of {B} cell lymphoma: an exposome wide analysis.},
      journal      = {International journal of cancer},
      volume       = {148},
      number       = {9},
      issn         = {1097-0215},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2020-02338},
      pages        = {2115-2128},
      year         = {2021},
      note         = {2021 May 1;148(9):2115-2128},
      abstract     = {To better understand the role of individual and lifestyle
                      factors in human disease, an exposome-wide association study
                      was performed to investigate within a single study
                      anthropometry measures and lifestyle factors previously
                      associated with B-cell lymphoma (BCL). Within the European
                      Prospective Investigation into Cancer and nutrition study,
                      2,402 incident BCL cases were diagnosed from 475,426
                      participants that were followed-up on average 14 years.
                      Standard and penalized Cox regression models as well as
                      principal component (PC) analysis were used to evaluate 84
                      exposures in relation to BCL risk. Standard and penalized
                      Cox regression models showed a positive association between
                      anthropometric measures and BCL and multiple myeloma/plasma
                      cell neoplasm (MM). The penalized Cox models additionally
                      showed the association between several exposures from
                      categories of physical activity, smoking status, medical
                      history, socioeconomic position, and diet and BCL and/or the
                      subtypes. PC analyses confirmed the individual associations
                      but also showed additional observations. The PC5 including
                      anthropometry, was positively associated with BCL, diffuse
                      large B-cell lymphoma (DLBCL), and MM. There was a
                      significant positive association between consumption of
                      sugar and confectionary (PC11) and follicular lymphoma risk,
                      and an inverse association between fish and shellfish and
                      Vitamin D (PC15) and DLBCL risk. The PC1 including features
                      of the Mediterranean diet and diet with lower inflammatory
                      score showed an inverse association with BCL risk, while the
                      PC7, including dairy, was positively associated with BCL and
                      DLBCL risk. Physical activity (PC10) was positively
                      associated with DLBCL risk among women. This study provided
                      informative insights on the etiology of BCL.},
      cin          = {C020 / C055},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C055-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33128820},
      doi          = {10.1002/ijc.33369},
      url          = {https://inrepo02.dkfz.de/record/164247},
}