Journal Article

DKFZ-2020-02338

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Association between anthropometry and lifestyle factors and risk of B cell lymphoma: an exposome wide analysis.

Saberi Hosnijeh, F. ; Casabonne, D. ; Nieters, A. ; Solans, M. ; Naudin, S. ; Ferrari, P. ; Mckay, J. D. ; Benavente, Y. ; Weiderpass, E. ; Freisling, H. ; Severi, G. ; Boutron Ruault, M.-C. ; Besson, C. ; Agnoli, C. ; Masala, G. ; Sacerdote, C. ; Tumino, R. ; Huerta, J. M. ; Amiano, P. ; Rodriguez-Barranco, M. ; Bonet, C. ; Barricarte, A. ; Christakoudi, S. ; Knuppel, A. ; Bueno-de-Mesquita, B. ; Schulze, M. B. ; Kaaks, R.DKFZ* ; Canzian, F.DKFZ* ; Späth, F. ; Jerkeman, M. ; Rylander, C. ; Tjønneland, A. ; Olsen, A. ; Borch, K. B. ; Vermeulen, R.

2021
Wiley-Liss Bognor Regis

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/ijc.33369

Abstract: To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2,402 incident BCL cases were diagnosed from 475,426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component (PC) analysis were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, and diet and BCL and/or the subtypes. PC analyses confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL), and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL.

Note: 2021 May 1;148(9):2115-2128

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)
2. C055 Genomische Epidemiologie (C055)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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