%0 Journal Article
%A Cai, Lina
%A Wheeler, Eleanor
%A Kerrison, Nicola D
%A Luan, Jian'an
%A Deloukas, Panos
%A Franks, Paul W
%A Amiano, Pilar
%A Ardanaz, Eva
%A Bonet, Catalina
%A Fagherazzi, Guy
%A Groop, Leif C
%A Kaaks, Rudolf
%A Huerta, José María
%A Masala, Giovanna
%A Nilsson, Peter M
%A Overvad, Kim
%A Pala, Valeria
%A Panico, Salvatore
%A Rodriguez-Barranco, Miguel
%A Rolandsson, Olov
%A Sacerdote, Carlotta
%A Schulze, Matthias B
%A Spijkerman, Annemieke M W
%A Tjonneland, Anne
%A Tumino, Rosario
%A van der Schouw, Yvonne T
%A Sharp, Stephen J
%A Forouhi, Nita G
%A Riboli, Elio
%A McCarthy, Mark I
%A Barroso, Inês
%A Langenberg, Claudia
%A Wareham, Nicholas J
%T Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study.
%J Scientific data
%V 7
%N 1
%@ 2052-4463
%C London
%I Nature Publ. Group
%M DKFZ-2020-02487
%P 393
%D 2020
%Z 2020 Nov 13;7(1):393
%X Type 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct project, centred in 8 countries in the European Prospective Investigations into Cancer and Nutrition study, is one of the largest prospective studies of T2D. Established as a nested case-cohort study to investigate the interplay between genetic and lifestyle behavioural factors on the risk of T2D, a total of 12,403 individuals were identified as incident T2D cases, and a representative sub-cohort of 16,154 individuals was selected from a larger cohort of 340,234 participants with a follow-up time of 3.99 million person-years. We describe the results from a genome-wide association analysis between more than 8.9 million SNPs and T2D risk among 22,326 individuals (9,978 cases and 12,348 non-cases) from the EPIC-InterAct study. The summary statistics to be shared provide a valuable resource to facilitate further investigations into the genetics of T2D.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33188205
%R 10.1038/s41597-020-00716-7
%U https://inrepo02.dkfz.de/record/165936