Journal Article

DKFZ-2020-02487

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study.

Cai, L. ; Wheeler, E. ; Kerrison, N. D. ; Luan, J. ; Deloukas, P. ; Franks, P. W. ; Amiano, P. ; Ardanaz, E. ; Bonet, C. ; Fagherazzi, G. ; Groop, L. C. ; Kaaks, R.DKFZ* ; Huerta, J. M. ; Masala, G. ; Nilsson, P. M. ; Overvad, K. ; Pala, V. ; Panico, S. ; Rodriguez-Barranco, M. ; Rolandsson, O. ; Sacerdote, C. ; Schulze, M. B. ; Spijkerman, A. M. W. ; Tjonneland, A. ; Tumino, R. ; van der Schouw, Y. T. ; Sharp, S. J. ; Forouhi, N. G. ; Riboli, E. ; McCarthy, M. I. ; Barroso, I. ; Langenberg, C. ; Wareham, N. J.

2020
Nature Publ. Group London

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Please use a persistent id in citations: doi:10.1038/s41597-020-00716-7

Abstract: Type 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct project, centred in 8 countries in the European Prospective Investigations into Cancer and Nutrition study, is one of the largest prospective studies of T2D. Established as a nested case-cohort study to investigate the interplay between genetic and lifestyle behavioural factors on the risk of T2D, a total of 12,403 individuals were identified as incident T2D cases, and a representative sub-cohort of 16,154 individuals was selected from a larger cohort of 340,234 participants with a follow-up time of 3.99 million person-years. We describe the results from a genome-wide association analysis between more than 8.9 million SNPs and T2D risk among 22,326 individuals (9,978 cases and 12,348 non-cases) from the EPIC-InterAct study. The summary statistics to be shared provide a valuable resource to facilitate further investigations into the genetics of T2D.

Note: 2020 Nov 13;7(1):393

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 323 - Metabolic Dysfunction as Risk Factor (POF3-323) (POF3-323)

Appears in the scientific report 2020

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