TY  - JOUR
AU  - Cai, Lina
AU  - Wheeler, Eleanor
AU  - Kerrison, Nicola D
AU  - Luan, Jian'an
AU  - Deloukas, Panos
AU  - Franks, Paul W
AU  - Amiano, Pilar
AU  - Ardanaz, Eva
AU  - Bonet, Catalina
AU  - Fagherazzi, Guy
AU  - Groop, Leif C
AU  - Kaaks, Rudolf
AU  - Huerta, José María
AU  - Masala, Giovanna
AU  - Nilsson, Peter M
AU  - Overvad, Kim
AU  - Pala, Valeria
AU  - Panico, Salvatore
AU  - Rodriguez-Barranco, Miguel
AU  - Rolandsson, Olov
AU  - Sacerdote, Carlotta
AU  - Schulze, Matthias B
AU  - Spijkerman, Annemieke M W
AU  - Tjonneland, Anne
AU  - Tumino, Rosario
AU  - van der Schouw, Yvonne T
AU  - Sharp, Stephen J
AU  - Forouhi, Nita G
AU  - Riboli, Elio
AU  - McCarthy, Mark I
AU  - Barroso, Inês
AU  - Langenberg, Claudia
AU  - Wareham, Nicholas J
TI  - Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study.
JO  - Scientific data
VL  - 7
IS  - 1
SN  - 2052-4463
CY  - London
PB  - Nature Publ. Group
M1  - DKFZ-2020-02487
SP  - 393
PY  - 2020
N1  - 2020 Nov 13;7(1):393
AB  - Type 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct project, centred in 8 countries in the European Prospective Investigations into Cancer and Nutrition study, is one of the largest prospective studies of T2D. Established as a nested case-cohort study to investigate the interplay between genetic and lifestyle behavioural factors on the risk of T2D, a total of 12,403 individuals were identified as incident T2D cases, and a representative sub-cohort of 16,154 individuals was selected from a larger cohort of 340,234 participants with a follow-up time of 3.99 million person-years. We describe the results from a genome-wide association analysis between more than 8.9 million SNPs and T2D risk among 22,326 individuals (9,978 cases and 12,348 non-cases) from the EPIC-InterAct study. The summary statistics to be shared provide a valuable resource to facilitate further investigations into the genetics of T2D.
LB  - PUB:(DE-HGF)16
C6  - pmid:33188205
DO  - DOI:10.1038/s41597-020-00716-7
UR  - https://inrepo02.dkfz.de/record/165936
ER  -