%0 Journal Article
%A Zheng, Ju-Sheng
%A Luan, Jian'an
%A Sofianopoulou, Eleni
%A Imamura, Fumiaki
%A Stewart, Isobel D
%A Day, Felix R
%A Pietzner, Maik
%A Wheeler, Eleanor
%A Lotta, Luca A
%A Gundersen, Thomas E
%A Amiano, Pilar
%A Ardanaz, Eva
%A Chirlaque, María-Dolores
%A Fagherazzi, Guy
%A Franks, Paul W
%A Kaaks, Rudolf
%A Laouali, Nasser
%A Mancini, Francesca Romana
%A Nilsson, Peter M
%A Onland-Moret, N Charlotte
%A Olsen, Anja
%A Overvad, Kim
%A Panico, Salvatore
%A Palli, Domenico
%A Ricceri, Fulvio
%A Rolandsson, Olov
%A Spijkerman, Annemieke M W
%A Sánchez, María-José
%A Schulze, Matthias B
%A Sala, Núria
%A Sieri, Sabina
%A Tjønneland, Anne
%A Tumino, Rosario
%A van der Schouw, Yvonne T
%A Weiderpass, Elisabete
%A Riboli, Elio
%A Danesh, John
%A Butterworth, Adam S
%A Sharp, Stephen J
%A Langenberg, Claudia
%A Forouhi, Nita G
%A Wareham, Nicholas J
%T Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations.
%J Diabetes care
%V 44
%N 1
%@ 1935-5548
%C Alexandria, Va.
%I Assoc.
%M DKFZ-2020-02508
%P 98-106
%D 2021
%Z 2021 Jan;44(1):98-106
%X Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes.We conducted genome-wide association studies of plasma vitamin C among 52,018 individuals of European ancestry to discover novel genetic variants. We performed Mendelian randomization analyses to estimate the association of genetically predicted differences in plasma vitamin C with type 2 diabetes in up to 80,983 case participants and 842,909 noncase participants. We compared this estimate with the observational association between plasma vitamin C and incident type 2 diabetes, including 8,133 case participants and 11,073 noncase participants.We identified 11 genomic regions associated with plasma vitamin C (P < 5 × 10-8), with the strongest signal at SLC23A1, and 10 novel genetic loci including SLC23A3, CHPT1, BCAS3, SNRPF, RER1, MAF, GSTA5, RGS14, AKT1, and FADS1. Plasma vitamin C was inversely associated with type 2 diabetes (hazard ratio per SD 0.88; 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33203707
%R 10.2337/dc20-1328
%U https://inrepo02.dkfz.de/record/165959