Journal Article

DKFZ-2020-02508

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations.

Zheng, J.-S. ; Luan, J. ; Sofianopoulou, E. ; Imamura, F. ; Stewart, I. D. ; Day, F. R. ; Pietzner, M. ; Wheeler, E. ; Lotta, L. A. ; Gundersen, T. E. ; Amiano, P. ; Ardanaz, E. ; Chirlaque, M.-D. ; Fagherazzi, G. ; Franks, P. W. ; Kaaks, R.DKFZ* ; Laouali, N. ; Mancini, F. R. ; Nilsson, P. M. ; Onland-Moret, N. C. ; Olsen, A. ; Overvad, K. ; Panico, S. ; Palli, D. ; Ricceri, F. ; Rolandsson, O. ; Spijkerman, A. M. W. ; Sánchez, M.-J. ; Schulze, M. B. ; Sala, N. ; Sieri, S. ; Tjønneland, A. ; Tumino, R. ; van der Schouw, Y. T. ; Weiderpass, E. ; Riboli, E. ; Danesh, J. ; Butterworth, A. S. ; Sharp, S. J. ; Langenberg, C. ; Forouhi, N. G. ; Wareham, N. J.

2021
Assoc. Alexandria, Va.

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Please use a persistent id in citations: doi:10.2337/dc20-1328

Abstract: Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes.We conducted genome-wide association studies of plasma vitamin C among 52,018 individuals of European ancestry to discover novel genetic variants. We performed Mendelian randomization analyses to estimate the association of genetically predicted differences in plasma vitamin C with type 2 diabetes in up to 80,983 case participants and 842,909 noncase participants. We compared this estimate with the observational association between plasma vitamin C and incident type 2 diabetes, including 8,133 case participants and 11,073 noncase participants.We identified 11 genomic regions associated with plasma vitamin C (P < 5 × 10-8), with the strongest signal at SLC23A1, and 10 novel genetic loci including SLC23A3, CHPT1, BCAS3, SNRPF, RER1, MAF, GSTA5, RGS14, AKT1, and FADS1. Plasma vitamin C was inversely associated with type 2 diabetes (hazard ratio per SD 0.88; 95% CI 0.82, 0.94), but there was no association between genetically predicted plasma vitamin C (excluding FADS1 variant due to its apparent pleiotropic effect) and type 2 diabetes (1.03; 95% CI 0.96, 1.10).These findings indicate discordance between biochemically measured and genetically predicted plasma vitamin C levels in the association with type 2 diabetes among European populations. The null Mendelian randomization findings provide no strong evidence to suggest the use of vitamin C supplementation for type 2 diabetes prevention.

Note: 2021 Jan;44(1):98-106

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 15 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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