TY  - JOUR
AU  - Zheng, Ju-Sheng
AU  - Luan, Jian'an
AU  - Sofianopoulou, Eleni
AU  - Imamura, Fumiaki
AU  - Stewart, Isobel D
AU  - Day, Felix R
AU  - Pietzner, Maik
AU  - Wheeler, Eleanor
AU  - Lotta, Luca A
AU  - Gundersen, Thomas E
AU  - Amiano, Pilar
AU  - Ardanaz, Eva
AU  - Chirlaque, María-Dolores
AU  - Fagherazzi, Guy
AU  - Franks, Paul W
AU  - Kaaks, Rudolf
AU  - Laouali, Nasser
AU  - Mancini, Francesca Romana
AU  - Nilsson, Peter M
AU  - Onland-Moret, N Charlotte
AU  - Olsen, Anja
AU  - Overvad, Kim
AU  - Panico, Salvatore
AU  - Palli, Domenico
AU  - Ricceri, Fulvio
AU  - Rolandsson, Olov
AU  - Spijkerman, Annemieke M W
AU  - Sánchez, María-José
AU  - Schulze, Matthias B
AU  - Sala, Núria
AU  - Sieri, Sabina
AU  - Tjønneland, Anne
AU  - Tumino, Rosario
AU  - van der Schouw, Yvonne T
AU  - Weiderpass, Elisabete
AU  - Riboli, Elio
AU  - Danesh, John
AU  - Butterworth, Adam S
AU  - Sharp, Stephen J
AU  - Langenberg, Claudia
AU  - Forouhi, Nita G
AU  - Wareham, Nicholas J
TI  - Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations.
JO  - Diabetes care
VL  - 44
IS  - 1
SN  - 1935-5548
CY  - Alexandria, Va.
PB  - Assoc.
M1  - DKFZ-2020-02508
SP  - 98-106
PY  - 2021
N1  - 2021 Jan;44(1):98-106
AB  - Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes.We conducted genome-wide association studies of plasma vitamin C among 52,018 individuals of European ancestry to discover novel genetic variants. We performed Mendelian randomization analyses to estimate the association of genetically predicted differences in plasma vitamin C with type 2 diabetes in up to 80,983 case participants and 842,909 noncase participants. We compared this estimate with the observational association between plasma vitamin C and incident type 2 diabetes, including 8,133 case participants and 11,073 noncase participants.We identified 11 genomic regions associated with plasma vitamin C (P < 5 × 10-8), with the strongest signal at SLC23A1, and 10 novel genetic loci including SLC23A3, CHPT1, BCAS3, SNRPF, RER1, MAF, GSTA5, RGS14, AKT1, and FADS1. Plasma vitamin C was inversely associated with type 2 diabetes (hazard ratio per SD 0.88; 95
LB  - PUB:(DE-HGF)16
C6  - pmid:33203707
DO  - DOI:10.2337/dc20-1328
UR  - https://inrepo02.dkfz.de/record/165959
ER  -