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| Home > Publications database > Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations. > print |
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| 001 | 165959 | ||
| 005 | 20240229133516.0 | ||
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| 037 | _ | _ | |a DKFZ-2020-02508 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Zheng, Ju-Sheng |0 0000-0001-6560-4890 |b 0 |
| 245 | _ | _ | |a Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations. |
| 260 | _ | _ | |a Alexandria, Va. |c 2021 |b Assoc. |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1611323543_16310 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a 2021 Jan;44(1):98-106 |
| 520 | _ | _ | |a Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes.We conducted genome-wide association studies of plasma vitamin C among 52,018 individuals of European ancestry to discover novel genetic variants. We performed Mendelian randomization analyses to estimate the association of genetically predicted differences in plasma vitamin C with type 2 diabetes in up to 80,983 case participants and 842,909 noncase participants. We compared this estimate with the observational association between plasma vitamin C and incident type 2 diabetes, including 8,133 case participants and 11,073 noncase participants.We identified 11 genomic regions associated with plasma vitamin C (P < 5 × 10-8), with the strongest signal at SLC23A1, and 10 novel genetic loci including SLC23A3, CHPT1, BCAS3, SNRPF, RER1, MAF, GSTA5, RGS14, AKT1, and FADS1. Plasma vitamin C was inversely associated with type 2 diabetes (hazard ratio per SD 0.88; 95% CI 0.82, 0.94), but there was no association between genetically predicted plasma vitamin C (excluding FADS1 variant due to its apparent pleiotropic effect) and type 2 diabetes (1.03; 95% CI 0.96, 1.10).These findings indicate discordance between biochemically measured and genetically predicted plasma vitamin C levels in the association with type 2 diabetes among European populations. The null Mendelian randomization findings provide no strong evidence to suggest the use of vitamin C supplementation for type 2 diabetes prevention. |
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| 700 | 1 | _ | |a Luan, Jian'an |b 1 |
| 700 | 1 | _ | |a Sofianopoulou, Eleni |b 2 |
| 700 | 1 | _ | |a Imamura, Fumiaki |b 3 |
| 700 | 1 | _ | |a Stewart, Isobel D |b 4 |
| 700 | 1 | _ | |a Day, Felix R |b 5 |
| 700 | 1 | _ | |a Pietzner, Maik |b 6 |
| 700 | 1 | _ | |a Wheeler, Eleanor |b 7 |
| 700 | 1 | _ | |a Lotta, Luca A |0 0000-0002-2619-5956 |b 8 |
| 700 | 1 | _ | |a Gundersen, Thomas E |b 9 |
| 700 | 1 | _ | |a Amiano, Pilar |b 10 |
| 700 | 1 | _ | |a Ardanaz, Eva |b 11 |
| 700 | 1 | _ | |a Chirlaque, María-Dolores |b 12 |
| 700 | 1 | _ | |a Fagherazzi, Guy |0 0000-0001-5033-5966 |b 13 |
| 700 | 1 | _ | |a Franks, Paul W |0 0000-0002-0520-7604 |b 14 |
| 700 | 1 | _ | |a Kaaks, Rudolf |0 P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a |b 15 |u dkfz |
| 700 | 1 | _ | |a Laouali, Nasser |b 16 |
| 700 | 1 | _ | |a Mancini, Francesca Romana |b 17 |
| 700 | 1 | _ | |a Nilsson, Peter M |b 18 |
| 700 | 1 | _ | |a Onland-Moret, N Charlotte |b 19 |
| 700 | 1 | _ | |a Olsen, Anja |b 20 |
| 700 | 1 | _ | |a Overvad, Kim |b 21 |
| 700 | 1 | _ | |a Panico, Salvatore |b 22 |
| 700 | 1 | _ | |a Palli, Domenico |b 23 |
| 700 | 1 | _ | |a Ricceri, Fulvio |b 24 |
| 700 | 1 | _ | |a Rolandsson, Olov |0 0000-0002-1341-6828 |b 25 |
| 700 | 1 | _ | |a Spijkerman, Annemieke M W |b 26 |
| 700 | 1 | _ | |a Sánchez, María-José |b 27 |
| 700 | 1 | _ | |a Schulze, Matthias B |0 0000-0002-0830-5277 |b 28 |
| 700 | 1 | _ | |a Sala, Núria |b 29 |
| 700 | 1 | _ | |a Sieri, Sabina |b 30 |
| 700 | 1 | _ | |a Tjønneland, Anne |b 31 |
| 700 | 1 | _ | |a Tumino, Rosario |b 32 |
| 700 | 1 | _ | |a van der Schouw, Yvonne T |b 33 |
| 700 | 1 | _ | |a Weiderpass, Elisabete |b 34 |
| 700 | 1 | _ | |a Riboli, Elio |b 35 |
| 700 | 1 | _ | |a Danesh, John |b 36 |
| 700 | 1 | _ | |a Butterworth, Adam S |b 37 |
| 700 | 1 | _ | |a Sharp, Stephen J |b 38 |
| 700 | 1 | _ | |a Langenberg, Claudia |b 39 |
| 700 | 1 | _ | |a Forouhi, Nita G |0 0000-0002-5041-248X |b 40 |
| 700 | 1 | _ | |a Wareham, Nicholas J |0 0000-0003-1422-2993 |b 41 |
| 773 | _ | _ | |a 10.2337/dc20-1328 |g p. dc201328 - |0 PERI:(DE-600)1490520-6 |n 1 |p 98-106 |t Diabetes care |v 44 |y 2021 |x 1935-5548 |
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