Journal Article

DKFZ-2020-02526

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Childhood exposure to hunger: associations with health outcomes in later life and epigenetic markers.

Perna, L. (First author)DKFZ* ; Zhang, Y.DKFZ* ; Wild, B. ; Kliegel, M. ; Ihle, A. ; Schöttker, B.DKFZ* ; Mons, U.DKFZ* ; Brenner, H. (Last author)DKFZ*

2020
Future Medicine Ltd. London

This record in other databases:  

Please use a persistent id in citations: doi:10.2217/epi-2019-0333

Abstract: Aim: To assess associations of early exposure to hunger with depressive symptoms and cardiovascular disease (CVD) and to investigate possible epigenetic pathways. Patients & methods: Data were based on a German population-based cohort of older adults (n = 9631). Regression models were performed for health outcomes in later life. An epigenome-wide association study for early-life exposure to hunger was performed in a subgroup (n = 2221) with whole blood DNA methylation data. Results: Childhood exposure to hunger was associated with CVD and depressive symptoms in later life. Prenatal or infant exposure was strongly associated with depressive symptoms. No CpG reached epigenome-wide significance after multiple testing correction. Conclusion: Childhood hunger is a risk factor for depressive symptoms and CVD at older age. DNA methylation could not explain this association.

Note: #EA:C070#LA:C070#2020 Nov;12(21):1861-1870

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Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)
2. M050 Krebsprävention (M050)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Essential Science Indicators ; IF < 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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