000166146 001__ 166146
000166146 005__ 20240229123221.0
000166146 037__ $$aDKFZ-2020-02654
000166146 1001_ $$0P:(DE-He78)8cc7a5c2b253317f7b005e2e6a3b7a05$$aSkuza, Raphael$$b0$$udkfz
000166146 245__ $$aFLASH Effect:An investigation into radical dynamics of H2O
000166146 260__ $$c2020
000166146 3367_ $$2DataCite$$aOutput Types/Supervised Student Publication
000166146 3367_ $$02$$2EndNote$$aThesis
000166146 3367_ $$2BibTeX$$aMASTERSTHESIS
000166146 3367_ $$2DRIVER$$amasterThesis
000166146 3367_ $$0PUB:(DE-HGF)19$$2PUB:(DE-HGF)$$aMaster Thesis$$bmaster$$mmaster$$s1608296610_32509
000166146 3367_ $$2ORCID$$aSUPERVISED_STUDENT_PUBLICATION
000166146 502__ $$aMasterarbeit, Universität Heidelberg, 2020$$bMasterarbeit$$cUniversität Heidelberg$$gFakultät für Physik und Astronomie
000166146 520__ $$aFLASH polarizes the radiotherapy-community: When mice and bacteria areirradiated with ultra high dose-rates, which exceed 40 Gy s−1, a radioprotectiveeffect can be observed when reaching or passing a critical dose. In 2019, thispeculiar radioprotective effect was observed in humans for the first time. In orderto implement FLASH as a new technique in clinics, one has to understand howthe effect mechanism works. This master thesis contributes to the understandingof FLASH by investigating the dynamics of the radicals which are producedduring irradiation. Furthermore, also the Oxygen Depletion Hypothesis (ODH)is investigated and if it is able to explain the FLASH effect. In order to achievethat, TRAXChem is used as a simulation program which is able to outputall the necessary information about the radical dynamics. Furthermore, theoxygen depletion effect will be described and a pathway is shown in orderto quantify the depletion of oxygen. Moreover, not only the micro-moleculardistribution of radicals is investigated but also the macro-molecular distribution.For that, a mapping between the micro- and macro-molecular distribution will beshown. This can be used in order to assess if it is possible in clinics to generatehomogeneous radical distributions in a larger volume. In the end, one importantquestion should be answered: Is FLASH a physical or biological effect?
000166146 536__ $$0G:(DE-HGF)POF3-315$$a315 - Imaging and radiooncology (POF3-315)$$cPOF3-315$$fPOF III$$x0
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000166146 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)8cc7a5c2b253317f7b005e2e6a3b7a05$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000166146 9131_ $$0G:(DE-HGF)POF3-315$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vImaging and radiooncology$$x0
000166146 9141_ $$y2020
000166146 9201_ $$0I:(DE-He78)E041-20160331$$kE041$$lE041 Medizinische Physik in der Radioonkologie$$x0
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000166146 980__ $$aVDB
000166146 980__ $$aI:(DE-He78)E041-20160331
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