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| Home > Publications database > FLASH Effect:An investigation into radical dynamics of H2O |
| Master Thesis | DKFZ-2020-02654 |
2020
Abstract: FLASH polarizes the radiotherapy-community: When mice and bacteria areirradiated with ultra high dose-rates, which exceed 40 Gy s−1, a radioprotectiveeffect can be observed when reaching or passing a critical dose. In 2019, thispeculiar radioprotective effect was observed in humans for the first time. In orderto implement FLASH as a new technique in clinics, one has to understand howthe effect mechanism works. This master thesis contributes to the understandingof FLASH by investigating the dynamics of the radicals which are producedduring irradiation. Furthermore, also the Oxygen Depletion Hypothesis (ODH)is investigated and if it is able to explain the FLASH effect. In order to achievethat, TRAXChem is used as a simulation program which is able to outputall the necessary information about the radical dynamics. Furthermore, theoxygen depletion effect will be described and a pathway is shown in orderto quantify the depletion of oxygen. Moreover, not only the micro-moleculardistribution of radicals is investigated but also the macro-molecular distribution.For that, a mapping between the micro- and macro-molecular distribution will beshown. This can be used in order to assess if it is possible in clinics to generatehomogeneous radical distributions in a larger volume. In the end, one importantquestion should be answered: Is FLASH a physical or biological effect?
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