% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@MASTERSTHESIS{Skuza:166146,
      author       = {R. Skuza$^*$},
      title        = {{FLASH} {E}ffect:{A}n investigation into radical dynamics
                      of {H}2{O}},
      school       = {Universität Heidelberg},
      type         = {Masterarbeit},
      reportid     = {DKFZ-2020-02654},
      year         = {2020},
      note         = {Masterarbeit, Universität Heidelberg, 2020},
      abstract     = {FLASH polarizes the radiotherapy-community: When mice and
                      bacteria areirradiated with ultra high dose-rates, which
                      exceed 40 Gy s−1, a radioprotectiveeffect can be observed
                      when reaching or passing a critical dose. In 2019,
                      thispeculiar radioprotective effect was observed in humans
                      for the first time. In orderto implement FLASH as a new
                      technique in clinics, one has to understand howthe effect
                      mechanism works. This master thesis contributes to the
                      understandingof FLASH by investigating the dynamics of the
                      radicals which are producedduring irradiation. Furthermore,
                      also the Oxygen Depletion Hypothesis (ODH)is investigated
                      and if it is able to explain the FLASH effect. In order to
                      achievethat, TRAXChem is used as a simulation program which
                      is able to outputall the necessary information about the
                      radical dynamics. Furthermore, theoxygen depletion effect
                      will be described and a pathway is shown in orderto quantify
                      the depletion of oxygen. Moreover, not only the
                      micro-moleculardistribution of radicals is investigated but
                      also the macro-molecular distribution.For that, a mapping
                      between the micro- and macro-molecular distribution will
                      beshown. This can be used in order to assess if it is
                      possible in clinics to generatehomogeneous radical
                      distributions in a larger volume. In the end, one
                      importantquestion should be answered: Is FLASH a physical or
                      biological effect?},
      cin          = {E041},
      cid          = {I:(DE-He78)E041-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)19},
      url          = {https://inrepo02.dkfz.de/record/166146},
}