000166153 001__ 166153
000166153 005__ 20240229123221.0
000166153 037__ $$aDKFZ-2020-02658
000166153 1001_ $$0P:(DE-He78)84cedecbe48f90adc2a1453780bdaf33$$aVolz, Lennart$$b0$$gmale$$udkfz
000166153 245__ $$aParticle imaging for daily in-roomimage guidance in particle therapy
000166153 260__ $$c2020
000166153 3367_ $$2DataCite$$aOutput Types/Dissertation
000166153 3367_ $$2ORCID$$aDISSERTATION
000166153 3367_ $$2BibTeX$$aPHDTHESIS
000166153 3367_ $$02$$2EndNote$$aThesis
000166153 3367_ $$0PUB:(DE-HGF)11$$2PUB:(DE-HGF)$$aDissertation / PhD Thesis$$bphd$$mphd$$s1608287369_32509
000166153 3367_ $$2DRIVER$$adoctoralThesis
000166153 502__ $$aDissertation, Universität Heidelberg, 2020$$bDissertation$$cUniversität Heidelberg$$gFakultät für Physik und Astronomie
000166153 520__ $$aParticle therapy exploits the highly localized depth dose profile of protons andlight ions to deliver a high dose to the target while largely sparing surroundinghealthy tissue. The steep dose gradient at the end of the ions range, knownas the Bragg peak, however, also makes particle therapy sensitive to rangeuncertainties. In current clinical practice, a major cause of range uncertaintiesresides in the conversion of the treatment planning x-ray CT to the patient specificrelative stopping power (RSP) map that is crucial for accurate treatmentplanning. By measuring the energy loss of particles after traversing the patient,particle imaging enables a more direct reconstruction of the RSP. In this thesis,different aspects towards the clinical implementation of particle imaging areinvestigated. First, a theoretical description of the point-spread function fordifferent particle radiography algorithms is developed in order to explain observedlimitations. A novel filtering technique to remove nuclear interactionevents in particle imaging is proposed and high quality experimental heliumion CTs are demonstrated. First results from an experimental comparison betweenparticle and x-ray CT modalities for RSP prediction in animal tissuesamples are presented. Furthermore, a novel technique for intra-treatment heliumion imaging based on a mixed helium/carbon beam is explored with thatrelative range changes in the millimeter regime were observable. Finally, novelparticle imaging detector designs are investigated. The thesis highlights thepotential of helium ion imaging for pre- and intra-treatment image guidancein particle therapy.
000166153 536__ $$0G:(DE-HGF)POF3-315$$a315 - Imaging and radiooncology (POF3-315)$$cPOF3-315$$fPOF III$$x0
000166153 909CO $$ooai:inrepo02.dkfz.de:166153$$pVDB
000166153 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)84cedecbe48f90adc2a1453780bdaf33$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000166153 9131_ $$0G:(DE-HGF)POF3-315$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vImaging and radiooncology$$x0
000166153 9141_ $$y2020
000166153 9201_ $$0I:(DE-He78)E041-20160331$$kE041$$lE041 Medizinische Physik in der Radioonkologie$$x0
000166153 980__ $$aphd
000166153 980__ $$aVDB
000166153 980__ $$aI:(DE-He78)E041-20160331
000166153 980__ $$aUNRESTRICTED