%0 Journal Article
%A Rothwell, Joseph A
%A Murphy, Neil
%A Bešević, Jelena
%A Kliemann, Nathalie
%A Jenab, Mazda
%A Ferrari, Pietro
%A Achaintre, David
%A Gicquiau, Audrey
%A Vozar, Béatrice
%A Scalbert, Augustin
%A Huybrechts, Inge
%A Freisling, Heinz
%A Prehn, Cornelia
%A Adamski, Jerzy
%A Cross, Amanda J
%A Pala, Valeria Maria
%A Boutron-Ruault, Marie-Christine
%A Dahm, Christina C
%A Overvad, Kim
%A Gram, Inger Torhild
%A Sandanger, Torkjel M
%A Skeie, Guri
%A Jakszyn, Paula
%A Tsilidis, Kostas K
%A Aleksandrova, Krasimira
%A Schulze, Matthias B
%A Hughes, David J
%A van Guelpen, Bethany
%A Bodén, Stina
%A Sánchez, Maria-José
%A Schmidt, Julie A
%A Katzke, Verena
%A Kühn, Tilman
%A Colorado-Yohar, Sandra
%A Tumino, Rosario
%A Bueno-de-Mesquita, Bas
%A Vineis, Paolo
%A Masala, Giovanna
%A Panico, Salvatore
%A Eriksen, Anne Kirstine
%A Tjønneland, Anne
%A Aune, Dagfinn
%A Weiderpass, Elisabete
%A Severi, Gianluca
%A Chajès, Véronique
%A Gunter, Marc J
%T Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort.
%J Clinical gastroenterology and hepatology
%V 20
%N 5
%@ 1542-3565
%C New York, NY
%I Elsevier Science
%M DKFZ-2020-02701
%P e1061-e1082
%D 2022
%Z 2022 May;20(5):e1061-e1082
%X Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer (EPIC) cohort.Scores reflecting adherence to the WCRF/AICR recommendations (scale 1-5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5,738 cancer-free EPIC participants with metabolomics data. Partial least squares regression was used to derive fatty acid and endogenous metabolite signatures of WCRF/AICR score in this group. In an independent set of 1,608 colorectal cancer cases and matched controls, odds ratios (OR) and 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33279777
%R 10.1016/j.cgh.2020.11.045
%U https://inrepo02.dkfz.de/record/166199