Journal Article

DKFZ-2020-02701

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort.

Rothwell, J. A. ; Murphy, N. ; Bešević, J. ; Kliemann, N. ; Jenab, M. ; Ferrari, P. ; Achaintre, D. ; Gicquiau, A. ; Vozar, B. ; Scalbert, A. ; Huybrechts, I. ; Freisling, H. ; Prehn, C. ; Adamski, J. ; Cross, A. J. ; Pala, V. M. ; Boutron-Ruault, M.-C. ; Dahm, C. C. ; Overvad, K. ; Gram, I. T. ; Sandanger, T. M. ; Skeie, G. ; Jakszyn, P. ; Tsilidis, K. K. ; Aleksandrova, K. ; Schulze, M. B. ; Hughes, D. J. ; van Guelpen, B. ; Bodén, S. ; Sánchez, M.-J. ; Schmidt, J. A. ; Katzke, V.DKFZ* ; Kühn, T.DKFZ* ; Colorado-Yohar, S. ; Tumino, R. ; Bueno-de-Mesquita, B. ; Vineis, P. ; Masala, G. ; Panico, S. ; Eriksen, A. K. ; Tjønneland, A. ; Aune, D. ; Weiderpass, E. ; Severi, G. ; Chajès, V. ; Gunter, M. J.

2022
Elsevier Science New York, NY

This record in other databases:  

Please use a persistent id in citations: doi:10.1016/j.cgh.2020.11.045

Abstract: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer (EPIC) cohort.Scores reflecting adherence to the WCRF/AICR recommendations (scale 1-5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5,738 cancer-free EPIC participants with metabolomics data. Partial least squares regression was used to derive fatty acid and endogenous metabolite signatures of WCRF/AICR score in this group. In an independent set of 1,608 colorectal cancer cases and matched controls, odds ratios (OR) and 95% confidence intervals (CI) were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.Higher WCRF/AICR scores were characterized by metabolic signatures of elevated odd-chain fatty acids, serine, glycine and specific phosphatidylcholines. Signatures were more strongly inversely associated with colorectal cancer risk (fatty acids: OR 0.51 per unit increase, 95% CI 0.29-0.90; endogenous metabolites: OR 0.62 per unit change, 95% CI 0.50-0.78) than the WCRF/AICR score (OR 0.93 per unit change, 95% CI 0.86-1.00) overall. Signature associations were stronger in male compared to female participants.Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.

Note: 2022 May;20(5):e1061-e1082

---

Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

---

Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Essential Science Indicators ; IF >= 10 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---