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000166199 1001_ $$aRothwell, Joseph A$$b0
000166199 245__ $$aMetabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort.
000166199 260__ $$aNew York, NY$$bElsevier Science$$c2022
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000166199 500__ $$a2022 May;20(5):e1061-e1082
000166199 520__ $$aColorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer (EPIC) cohort.Scores reflecting adherence to the WCRF/AICR recommendations (scale 1-5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5,738 cancer-free EPIC participants with metabolomics data. Partial least squares regression was used to derive fatty acid and endogenous metabolite signatures of WCRF/AICR score in this group. In an independent set of 1,608 colorectal cancer cases and matched controls, odds ratios (OR) and 95% confidence intervals (CI) were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.Higher WCRF/AICR scores were characterized by metabolic signatures of elevated odd-chain fatty acids, serine, glycine and specific phosphatidylcholines. Signatures were more strongly inversely associated with colorectal cancer risk (fatty acids: OR 0.51 per unit increase, 95% CI 0.29-0.90; endogenous metabolites: OR 0.62 per unit change, 95% CI 0.50-0.78) than the WCRF/AICR score (OR 0.93 per unit change, 95% CI 0.86-1.00) overall. Signature associations were stronger in male compared to female participants.Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
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000166199 7001_ $$aMurphy, Neil$$b1
000166199 7001_ $$aBešević, Jelena$$b2
000166199 7001_ $$aKliemann, Nathalie$$b3
000166199 7001_ $$aJenab, Mazda$$b4
000166199 7001_ $$aFerrari, Pietro$$b5
000166199 7001_ $$aAchaintre, David$$b6
000166199 7001_ $$aGicquiau, Audrey$$b7
000166199 7001_ $$aVozar, Béatrice$$b8
000166199 7001_ $$aScalbert, Augustin$$b9
000166199 7001_ $$aHuybrechts, Inge$$b10
000166199 7001_ $$aFreisling, Heinz$$b11
000166199 7001_ $$aPrehn, Cornelia$$b12
000166199 7001_ $$aAdamski, Jerzy$$b13
000166199 7001_ $$aCross, Amanda J$$b14
000166199 7001_ $$aPala, Valeria Maria$$b15
000166199 7001_ $$aBoutron-Ruault, Marie-Christine$$b16
000166199 7001_ $$aDahm, Christina C$$b17
000166199 7001_ $$aOvervad, Kim$$b18
000166199 7001_ $$aGram, Inger Torhild$$b19
000166199 7001_ $$aSandanger, Torkjel M$$b20
000166199 7001_ $$aSkeie, Guri$$b21
000166199 7001_ $$aJakszyn, Paula$$b22
000166199 7001_ $$aTsilidis, Kostas K$$b23
000166199 7001_ $$aAleksandrova, Krasimira$$b24
000166199 7001_ $$aSchulze, Matthias B$$b25
000166199 7001_ $$aHughes, David J$$b26
000166199 7001_ $$avan Guelpen, Bethany$$b27
000166199 7001_ $$aBodén, Stina$$b28
000166199 7001_ $$aSánchez, Maria-José$$b29
000166199 7001_ $$aSchmidt, Julie A$$b30
000166199 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b31$$udkfz
000166199 7001_ $$0P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aKühn, Tilman$$b32$$udkfz
000166199 7001_ $$aColorado-Yohar, Sandra$$b33
000166199 7001_ $$aTumino, Rosario$$b34
000166199 7001_ $$aBueno-de-Mesquita, Bas$$b35
000166199 7001_ $$aVineis, Paolo$$b36
000166199 7001_ $$aMasala, Giovanna$$b37
000166199 7001_ $$aPanico, Salvatore$$b38
000166199 7001_ $$aEriksen, Anne Kirstine$$b39
000166199 7001_ $$aTjønneland, Anne$$b40
000166199 7001_ $$aAune, Dagfinn$$b41
000166199 7001_ $$aWeiderpass, Elisabete$$b42
000166199 7001_ $$aSeveri, Gianluca$$b43
000166199 7001_ $$aChajès, Véronique$$b44
000166199 7001_ $$aGunter, Marc J$$b45
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