TY  - JOUR
AU  - Rothwell, Joseph A
AU  - Murphy, Neil
AU  - Bešević, Jelena
AU  - Kliemann, Nathalie
AU  - Jenab, Mazda
AU  - Ferrari, Pietro
AU  - Achaintre, David
AU  - Gicquiau, Audrey
AU  - Vozar, Béatrice
AU  - Scalbert, Augustin
AU  - Huybrechts, Inge
AU  - Freisling, Heinz
AU  - Prehn, Cornelia
AU  - Adamski, Jerzy
AU  - Cross, Amanda J
AU  - Pala, Valeria Maria
AU  - Boutron-Ruault, Marie-Christine
AU  - Dahm, Christina C
AU  - Overvad, Kim
AU  - Gram, Inger Torhild
AU  - Sandanger, Torkjel M
AU  - Skeie, Guri
AU  - Jakszyn, Paula
AU  - Tsilidis, Kostas K
AU  - Aleksandrova, Krasimira
AU  - Schulze, Matthias B
AU  - Hughes, David J
AU  - van Guelpen, Bethany
AU  - Bodén, Stina
AU  - Sánchez, Maria-José
AU  - Schmidt, Julie A
AU  - Katzke, Verena
AU  - Kühn, Tilman
AU  - Colorado-Yohar, Sandra
AU  - Tumino, Rosario
AU  - Bueno-de-Mesquita, Bas
AU  - Vineis, Paolo
AU  - Masala, Giovanna
AU  - Panico, Salvatore
AU  - Eriksen, Anne Kirstine
AU  - Tjønneland, Anne
AU  - Aune, Dagfinn
AU  - Weiderpass, Elisabete
AU  - Severi, Gianluca
AU  - Chajès, Véronique
AU  - Gunter, Marc J
TI  - Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort.
JO  - Clinical gastroenterology and hepatology
VL  - 20
IS  - 5
SN  - 1542-3565
CY  - New York, NY
PB  - Elsevier Science
M1  - DKFZ-2020-02701
SP  - e1061-e1082
PY  - 2022
N1  - 2022 May;20(5):e1061-e1082
AB  - Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer (EPIC) cohort.Scores reflecting adherence to the WCRF/AICR recommendations (scale 1-5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5,738 cancer-free EPIC participants with metabolomics data. Partial least squares regression was used to derive fatty acid and endogenous metabolite signatures of WCRF/AICR score in this group. In an independent set of 1,608 colorectal cancer cases and matched controls, odds ratios (OR) and 95
LB  - PUB:(DE-HGF)16
C6  - pmid:33279777
DO  - DOI:10.1016/j.cgh.2020.11.045
UR  - https://inrepo02.dkfz.de/record/166199
ER  -