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| 024 | 7 | _ | |a 10.1016/j.lungcan.2020.11.029 |2 doi |
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| 024 | 7 | _ | |a 0169-5002 |2 ISSN |
| 024 | 7 | _ | |a 1872-8332 |2 ISSN |
| 024 | 7 | _ | |a altmetric:96539301 |2 altmetric |
| 037 | _ | _ | |a DKFZ-2020-02942 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Jiang, Mei |b 0 |
| 245 | _ | _ | |a The relationship between body-mass index and overall survival in non-small cell lung cancer by sex, smoking status, and race: A pooled analysis of 20,937 International lung Cancer consortium (ILCCO) patients. |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2020 |b Elsevier |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1609334050_28516 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The relationship between Body-Mass-Index (BMI) and lung cancer prognosis is heterogeneous. We evaluated the impact of sex, smoking and race on the relationship between BMI and overall survival (OS) in non-small-cell-lung-cancer (NSCLC).Data from 16 individual ILCCO studies were pooled to assess interactions between BMI and the following factors on OS: self-reported race, smoking status and sex, using Cox models (adjusted hazard ratios; aHR) with interaction terms and adjusted penalized smoothing spline plots in stratified analyses.Among 20,937 NSCLC patients with BMI values, females = 47 %; never-smokers = 14 %; White-patients = 76 %. BMI showed differential survival according to race whereby compared to normal-BMI patients, being underweight was associated with poor survival among white patients (OS, aHR = 1.66) but not among black patients (aHR = 1.06; pinteraction = 0.02). Comparing overweight/obese to normal weight patients, Black NSCLC patients who were overweight/obese also had relatively better OS (pinteraction = 0.06) when compared to White-patients. BMI was least associated with survival in Asian-patients and never-smokers. The outcomes of female ever-smokers at the extremes of BMI were associated with worse outcomes in both the underweight (pinteraction<0.001) and obese categories (pinteraction = 0.004) relative to the normal-BMI category, when compared to male ever-smokers.Underweight and obese female ever-smokers were associated with worse outcomes in White-patients. These BMI associations were not observed in Asian-patients and never-smokers. Black-patients had more favorable outcomes in the extremes of BMI when compared to White-patients. Body composition in Black-patients, and NSCLC subtypes more commonly seen in Asian-patients and never-smokers, may account for differences in these BMI-OS relationships. |
| 536 | _ | _ | |a 313 - Cancer risk factors and prevention (POF3-313) |0 G:(DE-HGF)POF3-313 |c POF3-313 |f POF III |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Body mass index |2 Other |
| 650 | _ | 7 | |a Interaction |2 Other |
| 650 | _ | 7 | |a Lung cancer |2 Other |
| 650 | _ | 7 | |a Obesity |2 Other |
| 700 | 1 | _ | |a Fares, Aline F |b 1 |
| 700 | 1 | _ | |a Shepshelovich, Daniel |b 2 |
| 700 | 1 | _ | |a Yang, Ping |b 3 |
| 700 | 1 | _ | |a Christiani, David |b 4 |
| 700 | 1 | _ | |a Zhang, Jie |b 5 |
| 700 | 1 | _ | |a Shiraishi, Kouya |b 6 |
| 700 | 1 | _ | |a Ryan, Brid M |b 7 |
| 700 | 1 | _ | |a Chen, Chu |b 8 |
| 700 | 1 | _ | |a Schwartz, Ann G |b 9 |
| 700 | 1 | _ | |a Tardon, Adonina |b 10 |
| 700 | 1 | _ | |a Shete, Sanjay |b 11 |
| 700 | 1 | _ | |a Schabath, Matthew B |b 12 |
| 700 | 1 | _ | |a Teare, M Dawn |b 13 |
| 700 | 1 | _ | |a Le Marchand, Loic |b 14 |
| 700 | 1 | _ | |a Zhang, Zuo-Feng |b 15 |
| 700 | 1 | _ | |a Field, John K |b 16 |
| 700 | 1 | _ | |a Brenner, Hermann |0 P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2 |b 17 |u dkfz |
| 700 | 1 | _ | |a Diao, Nancy |b 18 |
| 700 | 1 | _ | |a Xie, Juntao |b 19 |
| 700 | 1 | _ | |a Kohno, Takashi |b 20 |
| 700 | 1 | _ | |a Harris, Curtis C |b 21 |
| 700 | 1 | _ | |a Wenzlaff, Angela S |b 22 |
| 700 | 1 | _ | |a Fernandez-Tardon, Guillermo |b 23 |
| 700 | 1 | _ | |a Ye, Yuanqing |b 24 |
| 700 | 1 | _ | |a Taylor, Fiona |b 25 |
| 700 | 1 | _ | |a Wilkens, Lynne R |b 26 |
| 700 | 1 | _ | |a Davies, Michael |b 27 |
| 700 | 1 | _ | |a Liu, Yi |b 28 |
| 700 | 1 | _ | |a Barnett, Matt J |b 29 |
| 700 | 1 | _ | |a Goodman, Gary E |b 30 |
| 700 | 1 | _ | |a Morgenstern, Hal |b 31 |
| 700 | 1 | _ | |a Holleczek, Bernd |b 32 |
| 700 | 1 | _ | |a Thomas, Sera |b 33 |
| 700 | 1 | _ | |a Brown, M Catherine |b 34 |
| 700 | 1 | _ | |a Hung, Rayjean J |b 35 |
| 700 | 1 | _ | |a Xu, Wei |b 36 |
| 700 | 1 | _ | |a Liu, Geoffrey |b 37 |
| 773 | _ | _ | |a 10.1016/j.lungcan.2020.11.029 |g Vol. 152, p. 58 - 65 |0 PERI:(DE-600)2025812-4 |p 58 - 65 |t Lung cancer |v 152 |y 2020 |x 0169-5002 |
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