Journal Article

DKFZ-2020-02942

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The relationship between body-mass index and overall survival in non-small cell lung cancer by sex, smoking status, and race: A pooled analysis of 20,937 International lung Cancer consortium (ILCCO) patients.

Jiang, M. ; Fares, A. F. ; Shepshelovich, D. ; Yang, P. ; Christiani, D. ; Zhang, J. ; Shiraishi, K. ; Ryan, B. M. ; Chen, C. ; Schwartz, A. G. ; Tardon, A. ; Shete, S. ; Schabath, M. B. ; Teare, M. D. ; Le Marchand, L. ; Zhang, Z.-F. ; Field, J. K. ; Brenner, H.DKFZ* ; Diao, N. ; Xie, J. ; Kohno, T. ; Harris, C. C. ; Wenzlaff, A. S. ; Fernandez-Tardon, G. ; Ye, Y. ; Taylor, F. ; Wilkens, L. R. ; Davies, M. ; Liu, Y. ; Barnett, M. J. ; Goodman, G. E. ; Morgenstern, H. ; Holleczek, B. ; Thomas, S. ; Brown, M. C. ; Hung, R. J. ; Xu, W. ; Liu, G.

2020
Elsevier Amsterdam [u.a.]

This record in other databases:  

Please use a persistent id in citations: doi:10.1016/j.lungcan.2020.11.029

Abstract: The relationship between Body-Mass-Index (BMI) and lung cancer prognosis is heterogeneous. We evaluated the impact of sex, smoking and race on the relationship between BMI and overall survival (OS) in non-small-cell-lung-cancer (NSCLC).Data from 16 individual ILCCO studies were pooled to assess interactions between BMI and the following factors on OS: self-reported race, smoking status and sex, using Cox models (adjusted hazard ratios; aHR) with interaction terms and adjusted penalized smoothing spline plots in stratified analyses.Among 20,937 NSCLC patients with BMI values, females = 47 %; never-smokers = 14 %; White-patients = 76 %. BMI showed differential survival according to race whereby compared to normal-BMI patients, being underweight was associated with poor survival among white patients (OS, aHR = 1.66) but not among black patients (aHR = 1.06; pinteraction = 0.02). Comparing overweight/obese to normal weight patients, Black NSCLC patients who were overweight/obese also had relatively better OS (pinteraction = 0.06) when compared to White-patients. BMI was least associated with survival in Asian-patients and never-smokers. The outcomes of female ever-smokers at the extremes of BMI were associated with worse outcomes in both the underweight (pinteraction<0.001) and obese categories (pinteraction = 0.004) relative to the normal-BMI category, when compared to male ever-smokers.Underweight and obese female ever-smokers were associated with worse outcomes in White-patients. These BMI associations were not observed in Asian-patients and never-smokers. Black-patients had more favorable outcomes in the extremes of BMI when compared to White-patients. Body composition in Black-patients, and NSCLC subtypes more commonly seen in Asian-patients and never-smokers, may account for differences in these BMI-OS relationships.

Keyword(s): Body mass index ; Interaction ; Lung cancer ; Obesity

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Contributing Institute(s):

1. C070 Klinische Epidemiologie und Alternf. (C070)
2. Präventive Onkologie (C120)
3. DKTK HD zentral (HD01)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2020

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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