Journal Article

DKFZ-2021-00092

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Occupational exposure to organic dust and risk of lymphoma subtypes in the EPILYMPH case-control study.

Cocco, P. ; Satta, G. ; Meloni, F. ; Pilia, I. ; Ahmed, F. ; Becker, N.DKFZ* ; Casabonne, D. ; de Sanjosé, S. ; Foretova, L. ; Maynadié, M. ; Nieters, A. ; Staines, A. ; 't Mannetje, A. ; Zucca, M. ; Ennas, M. G. ; Campagna, M. ; De Matteis, S. ; Benavente, Y.

2021
Finnish Inst. of Occupational Health Helsinki

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Please use a persistent id in citations: doi:10.5271/sjweh.3925

Abstract: Objectives This study aimed to estimate the risk of lymphoma and its major subtypes in relation to occupational exposure to specific organic dusts. Methods We explored the association in 1853 cases and 1997 controls who participated in the EpiLymph case-control study, conducted in six European countries in 1998-2004. Based on expert assessment of lifetime occupational exposures, we calculated the risk of the major lymphoma subtypes associated with exposure to six specific organic dusts, namely, flour, hardwood, softwood, natural textile, synthetic textile, and leather, and two generic (any types) groups: wood and textile dusts. Risk was predicted with unconditional regression modeling, adjusted by age, gender, study center, and education. Results We observed a 2.1-fold increase in risk of follicular lymphoma associated with ever exposure to leather dust [95% confidence interval (CI) 1.01-4.20]. After excluding subjects who ever worked in a farm or had ever been exposed to solvents, risk of B-cell lymphoma was elevated in relation to ever exposure to leather dust [odd ratio (OR) 2.2, 95% CI 1.00-4.78], but it was not supported by increasing trends with the exposure metrics. Risk of Hodgkin lymphoma was elevated (OR 2.0, 95% CI 0.95-4.30) for exposure to textile dust, with consistent upward trends by cumulative exposure and three independent exposure metrics combined (P=0.023, and P=0.0068, respectively). Conclusions Future, larger studies might provide further insights into the nature of the association we observed between exposure to textile dust and risk of Hodgkin lymphoma.

Note: 1 Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.2 Institute of Public Health, Hacettepe University, Ankara, Turkey.3 German Cancer Research Center, Heidelberg, Germany.4 Catalan Institute of Oncology, IDIBELL, Barcelona, Spain.5 Consorcio Centro de Investigación Biomédica en Red de Epidemiología y Salud

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Contributing Institute(s):

1. Personalisierte Früherkennung des Prostatakarzinoms (C130)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Social and Behavioral Sciences ; Essential Science Indicators ; IF < 5 ; JCR ; National-Konsortium ; SCOPUS ; Science Citation Index Expanded ; Social Sciences Citation Index ; Web of Science Core Collection

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