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@ARTICLE{Costa:166770,
      author       = {B. M. Costa$^*$ and M. Fletcher$^*$ and P. Boskovic$^*$ and
                      E. L. Ivanova$^*$ and T. Eisemann$^*$ and S. Lohr$^*$ and L.
                      Bunse$^*$ and M. Löwer and S. Burchard and A. Korshunov$^*$
                      and N. Coltella and M. Cusimano and L. Naldini and H.-K.
                      Liu$^*$ and M. Platten$^*$ and B. Radlwimmer$^*$ and P.
                      Angel$^*$ and H. Peterziel$^*$},
      title        = {{A} {S}et of {C}ell {L}ines {D}erived from a {G}enetic
                      {M}urine {G}lioblastoma {M}odel {R}ecapitulates {M}olecular
                      and {M}orphological {C}haracteristics of {H}uman {T}umors.},
      journal      = {Cancers},
      volume       = {13},
      number       = {2},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2021-00109},
      pages        = {230},
      year         = {2021},
      note         = {DKFZ-ZMBH Alliance#EA:A100#LA:A100# / HI-TRON},
      abstract     = {Glioblastomas (GBM) are the most aggressive tumors
                      affecting the central nervous system in adults, causing
                      death within, on average, 15 months after diagnosis.
                      Immunocompetent in-vivo models that closely mirror human GBM
                      are urgently needed for deciphering glioma biology and for
                      the development of effective treatment options. The murine
                      GBM cell lines currently available for engraftment in
                      immunocompetent mice are not only exiguous but also
                      inadequate in representing prominent characteristics of
                      human GBM such as infiltrative behavior, necrotic areas, and
                      pronounced tumor heterogeneity. Therefore, we generated a
                      set of glioblastoma cell lines by repeated in vivo passaging
                      of cells isolated from a neural stem cell-specific Pten/p53
                      double-knockout genetic mouse brain tumor model.
                      Transcriptome and genome analyses of the cell lines revealed
                      molecular heterogeneity comparable to that observed in human
                      glioblastoma. Upon orthotopic transplantation into syngeneic
                      hosts, they formed high-grade gliomas that faithfully
                      recapitulated the histopathological features, invasiveness
                      and immune cell infiltration characteristic of human
                      glioblastoma. These features make our cell lines unique and
                      useful tools to study multiple aspects of glioblastoma
                      pathomechanism and to test novel treatments in an intact
                      immune microenvironment.},
      keywords     = {glioblastoma (Other) / mouse model (Other) / syngeneic cell
                      line (Other)},
      cin          = {A100 / B060 / D170 / B300 / A240 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)A100-20160331 / I:(DE-He78)B060-20160331 /
                      I:(DE-He78)D170-20160331 / I:(DE-He78)B300-20160331 /
                      I:(DE-He78)A240-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33435218},
      doi          = {10.3390/cancers13020230},
      url          = {https://inrepo02.dkfz.de/record/166770},
}