%0 Journal Article
%A Ghoneim, Dalia H
%A Zhu, Jingjing
%A Zheng, Wei
%A Long, Jirong
%A Murff, Harvey J
%A Ye, Fei
%A Setiawan, Veronica Wendy
%A Wilkens, Lynne R
%A Khankari, Nikhil K
%A Haycock, Philip
%A Antwi, Samuel O
%A Yang, Yaohua
%A Arslan, Alan A
%A Beane Freeman, Laura E
%A Bracci, Paige M
%A Canzian, Federico
%A Du, Mengmeng
%A Gallinger, Steven
%A Giles, Graham G
%A Goodman, Phyllis J
%A Kooperberg, Charles
%A Le Marchand, Loïc
%A Neale, Rachel E
%A Scelo, Ghislaine
%A Visvanathan, Kala
%A White, Emily
%A Albanes, Demetrius
%A Amiano, Pilar
%A Andreotti, Gabriella
%A Babic, Ana
%A Bamlet, William R
%A Berndt, Sonja I
%A Brais, Lauren K
%A Brennan, Paul
%A Bueno-de-Mesquita, Bas
%A Buring, Julie E
%A Campbell, Peter T
%A Rabe, Kari G
%A Chanock, Stephen J
%A Duggal, Priya
%A Fuchs, Charles S
%A Gaziano, J Michael
%A Goggins, Michael G
%A Hackert, Thilo
%A Hassan, Manal M
%A Helzlsouer, Kathy J
%A Holly, Elizabeth A
%A Hoover, Robert N
%A Katske, Verena
%A Kurtz, Robert C
%A Lee, I-Min
%A Malats, Núria
%A Milne, Roger L
%A Murphy, Neil
%A Oberg, Ann L
%A Porta, Miquel
%A Rothman, Nathaniel
%A Sesso, Howard D
%A Silverman, Debra T
%A Thompson, Ian M
%A Wactawski-Wende, Jean
%A Wang, Xiaoliang
%A Wentzensen, Nicolas
%A Yu, Herbert
%A Zeleniuch-Jacquotte, Anne
%A Yu, Kai
%A Wolpin, Brian M
%A Jacobs, Eric J
%A Duell, Eric J
%A Risch, Harvey A
%A Petersen, Gloria M
%A Amundadottir, Laufey T
%A Kraft, Peter
%A Klein, Alison P
%A Stolzenberg-Solomon, Rachel Z
%A Shu, Xiao-Ou
%A Wu, Lang
%T Mendelian Randomization Analysis of n-6 Polyunsaturated Fatty Acid Levels and Pancreatic Cancer Risk.
%J Cancer epidemiology, biomarkers & prevention
%V 29
%N 12
%@ 1538-7755
%C Philadelphia, Pa.
%I AACR
%M DKFZ-2021-00166
%P 2735 - 2739
%D 2020
%X Whether circulating polyunsaturated fatty acid (PUFA) levels are associated with pancreatic cancer risk is uncertain. Mendelian randomization (MR) represents a study design using genetic instruments to better characterize the relationship between exposure and outcome.We utilized data from genome-wide association studies within the Pancreatic Cancer Cohort Consortium and Pancreatic Cancer Case-Control Consortium, involving approximately 9,269 cases and 12,530 controls of European descent, to evaluate associations between pancreatic cancer risk and genetically predicted plasma n-6 PUFA levels. Conventional MR analyses were performed using individual-level and summary-level data.Using genetic instruments, we did not find evidence of associations between genetically predicted plasma n-6 PUFA levels and pancreatic cancer risk [estimates per one SD increase in each PUFA-specific weighted genetic score using summary statistics: linoleic acid odds ratio (OR) = 1.00, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32967863
%2 pmc:PMC7710600
%R 10.1158/1055-9965.EPI-20-0651
%U https://inrepo02.dkfz.de/record/167147